Cutaneous Immunoglobulin G4-Related Systemic Disease

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Cutaneous Immunoglobulin G4-Related Systemic Disease Arezou Khosroshahi, MD, Mollie D. Carruthers, MD, Vikram Deshpande, MD, Leon Leb, MD, John I. Reed, MD, John H. Stone, MD, MPH The American Journal of Medicine Volume 124, Issue 10, Pages e7-e8 (October 2011) DOI: 10.1016/j.amjmed.2011.03.011 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Clinical, pathologic, and immunohistochemical findings in cutaneous immunoglobulin G4-related systemic disease. A, Nodular facial rash. B, Dense inflammatory infiltrate involving the deep dermal tissue and subcutaneous fat, composed of lymphocytes, plasma cells, and occasional eosinophils (hematoxylin–eosin stain). C, Virtually all plasma cells stain for immunoglobulin G4 (immunoglobulin G4 immunoperoxidase stain). D, Resolution of the nodular skin rash after treatment with rituximab. The American Journal of Medicine 2011 124, e7-e8DOI: (10.1016/j.amjmed.2011.03.011) Copyright © 2011 Elsevier Inc. Terms and Conditions