The threshold for immune cell reactivity to milk antigens decreases in cow’s milk allergy with intestinal symptoms Nadia Benlounes, PhD, Christophe Dupont,

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Presentation transcript:

The threshold for immune cell reactivity to milk antigens decreases in cow’s milk allergy with intestinal symptoms Nadia Benlounes, PhD, Christophe Dupont, MD, Céline Candalh, Marie-Agnès Blaton, Nicole Darmon, PhD, Jehan-François Desjeux, MD, Martine Heyman, PhD Journal of Allergy and Clinical Immunology Volume 98, Issue 4, Pages 781-789 (October 1996) DOI: 10.1016/S0091-6749(96)70127-6 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Effect of supernatants of PBMCs from infants with active CMA, unstimulated PBMCs (control), or stimulated PBMCs with intact or intestinally processed CMPs on intestinal permeability to ions and small markers (A) and HRP (B) in intact and degraded form, measured on intestinal HT29-19A cells. *Significantly different from control and intestinally processed CMP (p < 0.03). n, Number of infants tested; mS/cm2, μmol/hr · cm2, μEq/hr · cm2, ng/hr · cm2. Journal of Allergy and Clinical Immunology 1996 98, 781-789DOI: (10.1016/S0091-6749(96)70127-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Effect of supernatants of PBMCs from infants with active CMA, unstimulated PBMCs (control), or stimulated PBMCs with intact or intestinally processed CMPs on intestinal permeability to ions and small markers (A) and HRP (B) in intact and degraded form, measured on intestinal HT29-19A cells. *Significantly different from control and intestinally processed CMP (p < 0.03). n, Number of infants tested; mS/cm2, μmol/hr · cm2, μEq/hr · cm2, ng/hr · cm2. Journal of Allergy and Clinical Immunology 1996 98, 781-789DOI: (10.1016/S0091-6749(96)70127-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 TNF-α release from PBMCs (106/ml) stimulated with increasing amounts of CMPs. Shaded area, Zone in which the TNF-α concentration did not induce intestinal dysfunction.8 In infants with active CMA manifested by intestinal symptoms (n = 18), CMP doses as low as 2 μg/ml induced permeability disorders, whereas infants who had recovered from CMA (n = 5) secreted less TNF-α, even at the very high CMP concentration of 600 μg/ml. In contrast, in infants with active CMA manifested by skin symptoms (n = 11), TNF-α secretion remained low. Journal of Allergy and Clinical Immunology 1996 98, 781-789DOI: (10.1016/S0091-6749(96)70127-6) Copyright © 1996 Mosby, Inc. Terms and Conditions