C-Liang He, Joseph H. Szurszewski, Gianrico Farrugia Gastroenterology

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Presentation transcript:

Loss of interstitial cells of cajal and inhibitory innervation in insulin-dependent diabetes C-Liang He, Joseph H. Szurszewski, Gianrico Farrugia Gastroenterology Volume 121, Issue 2, Pages 427-434 (August 2001) DOI: 10.1053/gast.2001.26264 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig.1 Distribution of ICC.Overview of the distribution of ICC from the normal human jejunum (left) and from the jejunum of a patient with insulin-dependent diabetes (right).Each panel is made up of a montage of several fields of view.C-kit–immunopositive structures are shown in white.A decrease in c-kit–positive immunoreactivity was seen in all regions of the jejunum in the diabetic patient compared with the control (Bar, 100 μm).LM, longitudinal muscle; ICC-MY, ICC in the myenteric plexus region; CM, circular muscle. Gastroenterology 2001 121, 427-434DOI: (10.1053/gast.2001.26264) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig.2 Three-dimensional reconstruction of ICC networks.(A) A three-dimensional reconstruction of the ICC-MY and (B) a three-dimensional reconstruction of ICC in the inner circular muscle layer.The panels on the left are from control tissue, whereas the panels on the right are from tissue from the patient with diabetes.Note the decrease in c-kit immunopositivity in the myenteric plexus region of the patient compared with the control and the absence of ICC in the inner circular muscle layer of the patient.Bar, 20 μm. Gastroenterology 2001 121, 427-434DOI: (10.1053/gast.2001.26264) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig.3 PGP 9.5 immunoreactivity.Nerve fiber distribution within the circular muscle layer of control tissue (left panel) and from tissue from the patient with diabetes (right panel).PGP 9.5 immunoreactivity was markedly decreased in the patient with diabetes reflecting a decrease in total number of nerve fibers within the circular muscle layer.Bar, 20 μm. Gastroenterology 2001 121, 427-434DOI: (10.1053/gast.2001.26264) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig.4 Inhibitory innervation.The left-hand panels show the distribution of immunopositive nerve fibers in the circular muscle layer for (A) nNOS, (B) VIP, and (C) PACAP in control tissue, whereas the right panels show the corresponding images from tissue from the diabetic patient.Immunoreactivity for nNOS, VIP, and PACAP was reduced in the patient compared with controls, suggesting a decrease in inhibitory innervation.Bar, 20 μm. Gastroenterology 2001 121, 427-434DOI: (10.1053/gast.2001.26264) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig.5 Excitatory innervation.The left panel shows SP immunoreactive nerve fibers in the circular muscle layer from control tissue and the right panel from tissue from the patient with diabetes.SP immunoreactivity was increased in the diabetic patient compared with controls, suggesting an increase in excitatory innervation.Bar, 20 μm. Gastroenterology 2001 121, 427-434DOI: (10.1053/gast.2001.26264) Copyright © 2001 American Gastroenterological Association Terms and Conditions