Introduction of Parasympatholytics: M blockers: Atropine, Cyclopentolate, Scopolamine, Tropicamide N1 Blockers: Nicotine N2 Blockers: Tubocurarine, Atracurium

Parasympatholytic Atropine Pharmaceutical chemistry Possible Origin Physiochemical Properties Idea of Retro-synthesis Molecular pharmacology Mechanism of action: Anti-muscarinic Structure-based explanation of Therapeutic uses: Mydriatic for measuring refractive errors of the eyes, (week-2 week duration). Replaced by short acting anti-cholinergics, Antispasmodic, anti-dote for mushroom poisoning and antisecretory. Structure-based explanation of Side effects: dry mouth, blurred vision, Sandy eyes, tachycardia, constipation, restless and confusion. Analysis

Parasympatholytic Cyclopentolate (Cyclogyl) Pharmaceutical chemistry Possible Origin Physiochemical Properties Idea of Retro-synthesis Molecular pharmacology Mechanism of action: Structure-based explanation of Therapeutic uses: short acting for mydriasis (24 hours) Structure-based explanation of Side effects: Analysis

Parasympatholytic Scopolamine Pharmaceutical chemistry Possible Origin Physiochemical Properties Idea of Retro-synthesis Molecular pharmacology Mechanism of action: Structure-based explanation of Therapeutic uses: motion sickness, block short-term memory and anti-spasmodic Structure-based explanation of Side effects: Analysis

Parasympatholytic Tropicamide (Mydriacyl) Pharmaceutical chemistry Possible Origin Physiochemical Properties Idea of Retro-synthesis Molecular pharmacology Mechanism of action: Structure-based explanation of Therapeutic uses: short acting for mydriasis (6 hours) Structure-based explanation of Side effects: Analysis

Parasympatholytic Nicotine (Nicotinell) Pharmaceutical chemistry Possible Origin Physiochemical Properties Idea of Retro-synthesis Molecular pharmacology Mechanism of action: Ganglionic blocker (N2) Structure-based explanation of Therapeutic uses: none Structure-based explanation of Side effects: stimulation then paralysis of Ganglionic receptor, high blood pressure, increasing cardiac output, hypotension with high doses and low GI activity. Analysis

Parasympatholytic Tubocurarine Pharmaceutical chemistry Possible Origin Physiochemical Properties Idea of Retro-synthesis Molecular pharmacology Mechanism of action: Neuromuscular blocker (N1) Structure-based explanation of Therapeutic uses: Adjuvant drug in anaesthesia to facilitate intubation. Structure-based explanation of Side effects: it sometimes increases histamine release and causes hypotension (allergy). Thus it is rarely used. Analysis

Parasympatholytic Atracurium (Tracrium) Pharmaceutical chemistry Possible Origin Physiochemical Properties Idea of Retro-synthesis Molecular pharmacology Mechanism of action: Structure-based explanation of Therapeutic uses: Structure-based explanation of Side effects: well-tolerated Analysis