Mechanism underlying transient gestational-onset hypothyroidism–induced impairment of posttesticular sperm maturation in adult rats Jaganathan Anbalagan,

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Mechanism underlying transient gestational-onset hypothyroidism–induced impairment of posttesticular sperm maturation in adult rats Jaganathan Anbalagan, Ph.D., Arokya Mary Sashi, Ph.D., Ganapathy Vengatesh, M.Sc., Jone Arulrajadurai Stanley, M.Phil., Ramalingam Neelamohan, M.Phil., Michael Mariajoseph Aruldhas, Ph.D. Fertility and Sterility Volume 93, Issue 8, Pages 2491-2497 (May 2010) DOI: 10.1016/j.fertnstert.2010.02.005 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Impact of transient gestational-onset of hypothyroidism on epididymal weight (A), corpus and caudal sperm content (B), caudal sperm forward motility (C), 5α-reductase (5αR) 1 and 2 mRNA expression (D–F) and 5αR enzyme activity (G). Each bar represents mean ± SEM of five observations. Bars with the same letters are not statistically significantly different, whereas those with different letters are statistically significantly different at the P≤.05 level. Comparisons are between coeval control and experimental rats. DHT = 5α-dihydrotestosterone; OD = optical density. Agarose gel electrophoresis lanes (D and E): lane 1: 100 bp ladder; lane 2: group I, caput; lane 3: group II, caput; lane 4: group III, caput; lane 5: group IV, caput; lane 6: group I, corpus; lane 7: group II, corpus; lane 8: group III, corpus; lane 9: group IV, corpus; lane 10: group I, cauda; lane 11: group II, cauda; lane 12: group III, cauda; lane 13: group IV, cauda. Fertility and Sterility 2010 93, 2491-2497DOI: (10.1016/j.fertnstert.2010.02.005) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Impact of transient gestational-onset hypothyroidism on epididymal androgen receptor (AR) mRNA expression (A, B), AR protein expression (C, D), and nuclear and cytosolic AR ligand-binding activity (E). RPL19 = ribosomal protein L19; other abbreviations and explanations as in Figure 1. Agarose gel electrophoresis lanes (A) as in Figures 1D and 1E. Western blot detection lanes (C): lane 1: group I; lane 2: group II; lane 3: group III; lane 4: group IV. Fertility and Sterility 2010 93, 2491-2497DOI: (10.1016/j.fertnstert.2010.02.005) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions