Pharmacology in Drug Discovery Antagonism and course revision

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Presentation transcript:

Pharmacology in Drug Discovery Antagonism and course revision Terry Kenakin Ph.D., Dept Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC Antagonism and course revision May 30th -31st (2016). Salle M415, Pavillon Roger Gaudry, Université de Montréal, 2900 Boulevard Edouard-Montpetit Outline May 30th, 9 am-12:00 pm; Salle M415 General concepts of drug antagonism / orthosteric antagonism / competitive vs non-competitive antagonism / antagonist hemi-equilibria May 30th, 1:30-4 pm; Salle M415/ Partial agonism / inverse agonism / therapeutic applications of inverse agonism / in vivo antagonism (target coverage), Safety Pharmacology May 31st, 9 am-12:00 pm; Salle M415 Drug Development: ADME properties I: (Absorption, Distribution, Metabolism, Excretion) May 30th, 1:30-3:30 pm Drug Development: ADME properties II: (Metabolism, Excretion) / Whole Course Review