Improving Stem Cell Therapeutics with Mechanobiology

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Improving Stem Cell Therapeutics with Mechanobiology Jae-Won Shin, David J. Mooney  Cell Stem Cell  Volume 18, Issue 1, Pages 16-19 (January 2016) DOI: 10.1016/j.stem.2015.12.007 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Translating Stem Cell Mechanobiology to Preclinical Models Stem cells can be programmed ex vivo either on 2D or 3D hydrogels with tunable matrix stiffness (E) prior to injection. 3D hydrogels can also be used for the transplantation of stem cells to the body. Matrix degradation (τ) can regulate stem cell functions as well. Molecular pathways in stem cell mechanosensing can potentially be modulated by pharmacological or genetic strategies to impact regenerative capacity. Cell Stem Cell 2016 18, 16-19DOI: (10.1016/j.stem.2015.12.007) Copyright © 2016 Elsevier Inc. Terms and Conditions

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