PI3K isoform–selective inhibitors and PTEN induction decrease ERK phosphorylation. PI3K isoform–selective inhibitors and PTEN induction decrease ERK phosphorylation.

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PI3K isoform–selective inhibitors and PTEN induction decrease ERK phosphorylation. PI3K isoform–selective inhibitors and PTEN induction decrease ERK phosphorylation. A, BT-474 cells were treated with the PI3Kα-specific inhibitor BYL-719 (5 μmol/L; left); MDA-MB-468 cells were treated with the PI3Kβ-specific inhibitor GSK2311418A (1 μmol/L; center); CCRF-SB cells were treated with the PI3Kδ-specific inhibitor CAL101 (1 μmol/L; right). B, PTEN expression was induced in MDA-MB-468TR-PTEN cells by doxycycline (100 ng/mL). A and B, cells were collected at indicated times. Immunoblots show loss of phosphorylation of RAF–MEK–ERK with inhibition of PI3K isoforms or induction of PTEN. N.S., nonspecific band. Marie Will et al. Cancer Discovery 2014;4:334-347 ©2014 by American Association for Cancer Research