Exome-Wide Association Study of Pancreatic Cancer Risk

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Exome-Wide Association Study of Pancreatic Cancer Risk Robert C. Grant, Robert E. Denroche, Ayelet Borgida, Carl Virtanen, Natalie Cook, Alyssa L. Smith, Ashton A. Connor, Julie M. Wilson, Gloria Peterson, Nicholas J. Roberts, Alison P. Klein, Sean M. Grimmond, Andrew Biankin, Sean Cleary, Malcolm Moore, Mathieu Lemire, George Zogopoulos, Lincoln Stein, Steven Gallinger  Gastroenterology  Volume 154, Issue 3, Pages 719-722.e3 (February 2018) DOI: 10.1053/j.gastro.2017.10.015 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Power to detect a gene enriched for rare inactivating variants (RIVs) based on an empirical “spike-in” procedure. (A) Power at the exome-wide significance level. P < 2.5x10-6. (B) Power at the suggestive significance level P < .001. Gastroenterology 2018 154, 719-722.e3DOI: (10.1053/j.gastro.2017.10.015) Copyright © 2018 AGA Institute Terms and Conditions

Figure 2 Manhattan plots and quantile-quantile plots for gene-based case-control association analyses. (A) Rare inactivating variants (RIVs). (B) Rare damaging variants (RDVs). Gastroenterology 2018 154, 719-722.e3DOI: (10.1053/j.gastro.2017.10.015) Copyright © 2018 AGA Institute Terms and Conditions

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