Alessandra Pasut, Michael A. Rudnicki Cell Stem Cell

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Presentation transcript:

The Long, the Short, and the Micro: A PolyA Tale of Pax3 in Satellite Cells Alessandra Pasut, Michael A. Rudnicki Cell Stem Cell Volume 10, Issue 3, Pages 237-238 (March 2012) DOI: 10.1016/j.stem.2012.02.009 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Differential Regulation of Pax3 Expression in Hind Limb and Diaphragm Muscle (A) In hind limb, alternative polyadenylation (APA) preferentially occurs at the 2019 position, resulting in a 3′UTR containing the miR-206 target sequence and severely decreased expression of Pax3 mRNA in activated satellite cells (ASC) compared with that in quiescent satellite cells (QSC). (B) In the diaphragm, APA occurs predominantly at positions 345 or 612. Consequently a short Pax3 isoform lacking the miR-206 binding site is produced that escapes the regulation. Cell Stem Cell 2012 10, 237-238DOI: (10.1016/j.stem.2012.02.009) Copyright © 2012 Elsevier Inc. Terms and Conditions