Excitation BolsTORs Motor Neurons in ALS Mice

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Presentation transcript:

Excitation BolsTORs Motor Neurons in ALS Mice Mark P. Mattson Neuron Volume 80, Issue 1, Pages 1-3 (October 2013) DOI: 10.1016/j.neuron.2013.09.017 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Mechanisms by which Glutamate Receptor-Mediated Excitation May Protect Motor Neurons against SOD1 Mutations that Cause Inherited ALS CaMK, Ca2+/calmodulin-dependent protein kinase; CREB, cyclic AMP response element-binding protein; ER, endoplasmic reticulum; IL-1β, interleukin-1β; mTOR, mammalian target of rapamycin; NPP, neuroprotective proteins; SV, synaptic vesicle; TNFα, tumor necrosis factor α; VDCC, voltage-dependent Ca2+ channel. Neuron 2013 80, 1-3DOI: (10.1016/j.neuron.2013.09.017) Copyright © 2013 Elsevier Inc. Terms and Conditions