Tumor necrosis factor-α and the early vein graft

Slides:

Advertisements

Similar presentations

Scott Adam Sundick, MD, Marvin Weaver, MD, Peter L

Advertisements

Diet-induced obesity drives negative mouse vein graft wall remodeling

Patrick C. H. Hsieh, MD, Richard D. Kenagy, PhD, Eileen R

Accelerated aneurysmal dilation associated with apoptosis and inflammation in a newly developed calcium phosphate rodent abdominal aortic aneurysm model

In vivo electroporation of constitutively expressed HIF-1α plasmid DNA improves neovascularization in a mouse model of limb ischemia Geoffrey O. Ouma,

Endogenous superoxide dismutase activation by oral administration of riboflavin reduces abdominal aortic aneurysm formation in rats Zhenhai Yu, MD, Keisuke.

Xue Ma, MD, Jeffrey D. Pearce, MD, David B. Wilson, MD, William P

Kenneth M. DeSart, MD, Khayree Butler, MD, Kerri A

Perivascular innate immune events modulate early murine vein graft adaptations Binh T. Nguyen, MD, Peng Yu, MD, Ming Tao, MD, Shuai Hao, BS, Tianyu Jiang,

Celiprolol reduces the intimal thickening of autogenous vein grafts via an enhancement of nitric oxide function through an inhibition of superoxide production

Ezetimibe reduces intimal hyperplasia in rabbit jugular vein graft

VCAM-1 siRNA reduces neointimal formation after surgical mechanical injury of the rat carotid artery Yanming Qu, MD, Xiangen Shi, MD, Hongwei Zhang,

Lysyl oxidase expression in a rat model of arterial balloon injury

Gene transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel- coated polyester stent graft Hongshan Zhong, MD, Osamu Matsui, MD,

Duodenal Reflux Leads to Down Regulation of DNA Mismatch Repair Pathway in an Animal Model of Esophageal Cancer Pramod Bonde, MD, MS, Daqing Gao, PhD,

The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling

Gene transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel- coated polyester stent graft Hongshan Zhong, MD, Osamu Matsui, MD,

Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia- reperfusion injury Christine R. Mauro, MD, Ming Tao, MD, Peng.

Lipoplex gene transfer of inducible nitric oxide synthase inhibits the reactive intimal hyperplasia after expanded polytetrafluoroethylene bypass grafting

Robert A. Brenes, MD, Caroline C

Blood-derived smooth muscle cells as a target for gene delivery

A novel function for cadherin 11/osteoblast-cadherin in vascular smooth muscle cells: Modulation of cell migration and proliferation Thomas S. Monahan,

Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia Michael J. Osgood, MD, Kevin Sexton, MD, Igor Voskresensky, MD, Kyle.

Ryan M. McEnaney, MD, Ankur Shukla, MD, Michael C

Wai-ki Yiu, MBBS, MRCS, Stephen W. K. Cheng, MS, FRCS, Bauer E

Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats Keisuke Morimoto, MD, Tomomi Hasegawa,

Don't trust a vein graft to treat carotid aneurysm in patients with Behçet disease Xavier Berard, MD, Jean-Marc Corpataux, MD, Habib Taoufiq, MD, Gerard.

Tongue necrosis as an unusual presentation of carotid artery stenosis

Martin Björck, MD, PhD, David Bergqvist, MD, PhD

Influence of endothelial cell seeding on platelet deposition and patency in small- diameter Dacron arterial grafts Brent T. Allen, M.D., Julie A. Long,

Diet-induced obesity drives negative mouse vein graft wall remodeling

Aging exacerbates neointimal formation, and increases proliferation and reduces susceptibility to apoptosis of vascular smooth muscle cells in mice Roberto.

Tissue factor pathway inhibitor-2 is induced by fluid shear stress in vascular smooth muscle cells and affects cell proliferation and survival Johan.

Wall shear modulation of cytokines in early vein grafts

Mechanosensitive transient receptor potential vanilloid type 1 channels contribute to vascular remodeling of rat fistula veins Yih-Sharng Chen, MD, PhD,

Long-term safety of cilostazol in patients with peripheral artery disease: The CASTLE study (Cilostazol: A Study in Long-term Effects) William R. Hiatt,

Sarpogrelate hydrochloride reduced intimal hyperplasia in experimental rabbit vein graft Akio Kodama, MD, Kimihiro Komori, MD, PhD, Keisuke Hattori, MD,

Reduction of myointimal hyperplasia after arterial anastomosis by local injection of transforming growth factor β3 Jonathan Ghosh, MD, MRCS, Mohammed.

Simvastatin suppresses experimental aortic aneurysm expansion

Antisense basic fibroblast growth factor gene transfer reduces early intimal thickening in a rabbit femoral artery balloon injury model David G. Neschis,

Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts Helen M.

Survivin expression is up-regulated in vascular injury and identifies a distinct cellular phenotype Hector F. Simosa, MD, Grace Wang, MD, XinXin Sui,

Navin K. Kapur, MD, Ce Bian, MD, Edward Lin, MD, Clayton B

Flow reversal promotes intimal thickening in vein grafts

Seung-Kee Min, MD, PhD, Richard D. Kenagy, PhD, Joseph P

Delayed inhaled carbon monoxide mediates the regression of established neointimal lesions Michael Madigan, MD, Fateh Entabi, MD, Brian Zuckerbraun, MD,

Murine ultrasound imaging for circumferential strain analyses in the angiotensin II abdominal aortic aneurysm model John T. Favreau, BS, Binh T. Nguyen,

Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis Masayuki Kubo, PhD, Tao-Sheng Li, MD, PhD, Takahiro.

Gene expression changes evoked in a venous segment exposed to arterial flow Deborah Abeles, MD, Stephanie Kwei, MD, George Stavrakis, MS, Yuzhi Zhang,

Identification of multiple genes with altered expression at the distal anastomosis of healing polytetrafluoroethylene grafts Juan A. Cordero, MD, William.

Stylocarotid artery syndrome

Revascularization of cerebral ischemia after previous bilateral extracranial-intracranial bypass procedures V.S. Sottiurai, MD, PhD, L. Herbert, MD,

Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling Akimasa Yamashita,

Rationale and practical techniques for mouse models of early vein graft adaptations Peng Yu, MD, Binh T. Nguyen, MD, Ming Tao, MD, Christina Campagna,

Yehuda G. Wolf, MD, Lars M. Rasmussen, MD, Yoav Sherman, MD, Warner P

Michael E. Landis, MDa, Edward C

Scott Adam Sundick, MD, Marvin Weaver, MD, Peter L

Functional analysis of cryopreserved veins

Vein interposition cuffs decrease the intimal hyperplastic response of polytetrafluoroethylene bypass grafts Mark Kissin, MD, Nikhil Kansal, MD, Peter.

Robert A. McCready, MD, Steven K. Miller, MD, Ronald C

Small-caliber heparin-coated ePTFE grafts reduce platelet deposition and neointimal hyperplasia in a baboon model Peter H Lin, MD, Changyi Chen, MD,

Macrophage depletion reduces monocyte chemotactic protein-1 and transforming growth factor-β1 in healing rat vein grafts Randal A Wolff, PhD, Jeffrey.

Michel Lacombe, MD Journal of Vascular Surgery

Follow-up evaluation after renal artery bypass surgery with use of carbon dioxide arteriography and color-flow duplex scanning Timothy R.S. Harward,

Short-term dexamethasone treatment inhibits vein graft thickening in hypercholesterolemic ApoE3Leiden transgenic mice Abbey Schepers, MD, Nuno M.M. Pires,

Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts Hiroshi Banno, MD, Yoshifumi Takei, PhD,

Luke S. Erdoes, MD, Timothy P. Milner, MD Journal of Vascular Surgery

A giant common carotid artery pseudoaneurysm after penetrating injury

Adipose phenotype predicts early human autogenous arteriovenous hemodialysis remodeling Christine R. Mauro, MD, Kui Ding, MD, PhD, Hui Xue, MD, MMSc,

Gene expression changes evoked in a venous segment exposed to arterial flow Deborah Abeles, MD, Stephanie Kwei, MD, George Stavrakis, MS, Yuzhi Zhang,

Presentation transcript:

Tumor necrosis factor-α and the early vein graft Zhihua Jiang, MD, PhD, Ankur Shukla, BS, Brett L. Miller, BS, Derek R. Espino, BS, Ming Tao, MD, Scott A. Berceli, MD, PhD, C. Keith Ozaki, MD Journal of Vascular Surgery Volume 45, Issue 1, Pages 169-176 (January 2007) DOI: 10.1016/j.jvs.2006.08.049 Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 1 Bilateral vein graft model with differential flow environments. Left panel, External jugular vein interposition in the common carotid artery was constructed with cuffed anastomosis. Right panel, All distal branches except the occipital artery were ligated to decrease the ipsilateral flow and gain compensatory increase in the blood flow on the opposite side. Adapted from Am J Physiol Heart Circ Physiol 2004;286:H240-5. Used with permission. Journal of Vascular Surgery 2007 45, 169-176DOI: (10.1016/j.jvs.2006.08.049) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 2 A, Shear stress, B development of neointima, and C expression of tumor necrosis factor-α (TNF-α) messenger RNA (mRNA) in low-flow and high-flow vein grafts over time. Both time and flow were identified as independent factors by two-way repeated measures analysis of variance (P < .001 for all three end points). Data are presented as means ± SEM. Journal of Vascular Surgery 2007 45, 169-176DOI: (10.1016/j.jvs.2006.08.049) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 3 Left panel, Pegylated soluble tumor necrosis factor receptor I (PEG sTNF-RI) immunoreactivity in a long-term treated graft (no counterstain). PEG sTNF-RI colocalizes with cells in the neointima. Arrowheads indicate internal elastic lamina. Right panel, Negative control (where the antibody was replaced with antibody dilution serum) was completely negative, suggesting the specificity of anti-PEG sTNF-RI immunostaining. Enzymatic 3,3’-diaminobenzidine precipitation was employed to visualize the specific positive staining (original × 400). Journal of Vascular Surgery 2007 45, 169-176DOI: (10.1016/j.jvs.2006.08.049) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 4 Summary of flow rate at the time of harvest, neointimal thickness, and internal elastic lamina (IEL) length for vein grafts with short-term (daily dosing for the first 5 postoperative days of a 28-day observation period) and long-term (daily dosing from 1 day preoperatively until the end of the 14-day observation) anti-tumor necrosis factor-α treatment. No significant difference was detected for both low-flow and high-flow grafts between treated vein grafts and vehicle controls. PEG sTNF-RI, Pegylated soluble tumor necrosis factor receptor 1. Data are presented as means ± SEM. Journal of Vascular Surgery 2007 45, 169-176DOI: (10.1016/j.jvs.2006.08.049) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 5 Upper panel, Density of TUNEL (A) and Ki-67 (B) positive cells in low-flow vein grafts with long-term antitumor necrosis factor-α treatment. Data are presented as means ± SEM. Lower panel, Representative images for TUNEL and Ki-67 from the same animal. The treated vein grafts tended to have more TUNEL-positive and less Ki-67–positive cells in the neointima, but these differences are not statistically significant. PEG sTNF-R1, Pegylated soluble tumor necrosis factor receptor 1; TUNEL, terminal deoxynucleotide transferase-mediated deoxy uridine triphosphate nick-end labeling. Journal of Vascular Surgery 2007 45, 169-176DOI: (10.1016/j.jvs.2006.08.049) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions