Lipotoxicity in NASH Journal of Hepatology

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Presentation transcript:

Lipotoxicity in NASH Journal of Hepatology Michael Fuchs, Arun J. Sanyal Journal of Hepatology Volume 56, Issue 1, Pages 291-293 (January 2012) DOI: 10.1016/j.jhep.2011.05.019 Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Lipotoxicity in NASH. (A) Flux and utilization of saturated fatty acids in the liver. (B) The adaptive response to ER stress in NASH. (C) The alarm response to ER stress in NASH. (D) Toll-like receptor 4 (TLR4) and tumor necrosis factor receptor (TNFR) signaling in NASH. (E) Death receptor signaling in NASH. Chol, cholesterol; SFA, saturated fatty acid; VLDL, very low density lipoprotein; ER, endoplasmic reticulum; ROS, reactive oxygen species; IRE1, inositol-requiring enzyme 1; JNK, c-Jun N-terminal kinase; PUMA, p53 upregulated modulator of apoptosis; PERK, PKR-like endoplasmic reticulum kinase; eIF2a, alpha subunit of the eukaryotic initiation factor 2; ATF4/6, activating transcription factor 4/6; CHOP, CCAAT/enhancer-binding homologous protein; Bim, Bcl-2 protein family member; DR5, death receptor 5. NASH, non-alcoholic fatty liver disease; XBP1, X-box protein 1; IP3, inositol triphosphate activated calcium channel; TRAF2, tumor necrosis factor receptor-associated factor 2; ASK1, apoptosis signal-regulating kinase 1; CHOP, C/EBP homologous protein; Bax, B-cell lymphoma 2-associated X protein; PUMA, p53 upregulated modulator of apoptosis; TIRAP, Toll/IL-1 receptor domain containing adaptor protein; MyD88, myeloid differentiation factor 88; IRAK, interleukin 1 receptor associated kinase; TRAF2/6, TNF receptor associated factor 2/6; NEMO, NFκB essential modulator; TRADD, TNF receptor associated death domain protein; RIP, receptor interacting protein; FADD, Fas-associated protein with death domain; BID, pro-apoptotic BCL-2 interacting domain; FoxO3a, forkhead box-containing protein, class O member 3a; TNFα, tumor necrosis factor α; NFκB, nuclear factor κ B; NRF2, NF-E2 related factor 2. Journal of Hepatology 2012 56, 291-293DOI: (10.1016/j.jhep.2011.05.019) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions