Emerging roles for platelets as immune and inflammatory cells

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Presentation transcript:

Emerging roles for platelets as immune and inflammatory cells by Craig N. Morrell, Angela A. Aggrey, Lesley M. Chapman, and Kristina L. Modjeski Blood Volume 123(18):2759-2767 May 1, 2014 ©2014 by American Society of Hematology

Schematic of platelet-derived immune mediators Schematic of platelet-derived immune mediators. 5-HT, serotonin; ADP, adenosine 5′-diphosphate; COX-1, cyclooxygenase 1; P-selectin glycoprotein ligand-1; TbxA, thromboxane; WBC, white blood cell; PSGL-1. Schematic of platelet-derived immune mediators. 5-HT, serotonin; ADP, adenosine 5′-diphosphate; COX-1, cyclooxygenase 1; P-selectin glycoprotein ligand-1; TbxA, thromboxane; WBC, white blood cell; PSGL-1. Craig N. Morrell et al. Blood 2014;123:2759-2767 ©2014 by American Society of Hematology

Platelet and liver sinusoid interactions in a Plasmodium berghei–infected mouse (* denotes platelets). Platelet and liver sinusoid interactions in a Plasmodium berghei–infected mouse (* denotes platelets). Craig N. Morrell et al. Blood 2014;123:2759-2767 ©2014 by American Society of Hematology