Gut Microbiota: The Link to Your Second Brain

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Gut Microbiota: The Link to Your Second Brain Vanessa Ridaura, Yasmine Belkaid Cell Volume 161, Issue 2, Pages 193-194 (April 2015) DOI: 10.1016/j.cell.2015.03.033 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Role of the Microbiota in Serotonin Production The gut microbiota influences the number and function of enterochromaffin cells, thereby promoting the release of serotonin (5-HT). The microbiota promotes serotonin production via various metabolites, including short-chain fatty acid (SCFA). Serotonin can act on various physiological systems promoting gut motility, secretory reflexes, and platelet function. The action of serotonin can be local as well as distal (on bone development and cardiac function) via platelet-mediated transport. Serotonin can also influence the immune system, an effect that could feed back on enterochromaffin cells and the microbiota itself. Defined microbes have also been shown to produce serotonin, a pathway that may further link the microbiota and host serotonin levels. Cell 2015 161, 193-194DOI: (10.1016/j.cell.2015.03.033) Copyright © 2015 Elsevier Inc. Terms and Conditions