Volume 21, Issue 4, Pages (November 2014)

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Volume 21, Issue 4, Pages 309-316 (November 2014) Experimental studies of remarkable monoamine releases and neural resistance to the transient ischemia and reperfusion Kanji Yoshimoto, Akira Namera, Yousuke Arima, Takahiro Nagao, Hiroh Saji, Tomokazu Takasaka, Takeshi Uemura, Yoshihisa Watanabe, Shuichi Ueda, Masataka Nagao Pathophysiology Volume 21, Issue 4, Pages 309-316 (November 2014) DOI: 10.1016/j.pathophys.2014.08.005 Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 1 Dopamine (DA) and serotonin (5-HT) release (fM/20min) in the nucleus accumbens (ACC) of rats treated with the coagulation of bilateral vertebral arteries, (n=6). Pathophysiology 2014 21, 309-316DOI: (10.1016/j.pathophys.2014.08.005) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 2 Time-course changes of dopamine (DA) and serotonin (5-HT) release in the nucleus accumbens (ACC) at the time of four-vessel occlusion (4VO). ACC DA and 5-HT release of rats treated with the coagulation of bilateral vertebral arteries increased at the time of 10-min clipping of common carotid arteries. The closed circles and open circles indicate the 4VO-treated rats and sham-control rats, respectively. The values are means±standard deviations (SD). [Two-way analysis of variance (ANOVA) and Bonferroni post hoc test] *p<0.05 and ***p<0.001 compared with the sham-control group (n=6–8). Pathophysiology 2014 21, 309-316DOI: (10.1016/j.pathophys.2014.08.005) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 3 Basal dopamine (DA) and serotonin (5-HT) release in the nucleus accumbens (ACC), lateral hypothalamus (LH), and frontal cortex (FC) of rats upon 4 days of reperfusion after four-vessel occlusion (4VO). The values are means±standard deviations (SD). *p<0.05 and **p<0.01 [two-way analysis of variance (ANOVA) and Bonferroni post hoc test; n=10–12 in each group.] The closed column and open column indicate the 4VO-treated rats and sham-control rats, respectively. Pathophysiology 2014 21, 309-316DOI: (10.1016/j.pathophys.2014.08.005) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 4 Time-course changes of dopamine (DA) release in the nucleus accumbens (ACC) (A), lateral hypothalamus (LH) (B), and frontal cortex (FC) (C) upon 4 days of reperfusion after treatment with four-vessel occlusion (4VO). The bars show the K+ perfusion medium for 20min. The closed circles and open circles indicate the 4VO-treated rats and sham-control rats, respectively. The data are shown as mean±standard deviation (SD). [Two-way analysis of variance (ANOVA) and Bonferroni post hoc test; n=6–8] *p<0.05 and **p<0.01. Time-course changes of serotonin (5-HT) release in the ACC (D), LH (E), and FC (F) upon 4 days of reperfusion after treatment with the 4VO. The bars show the K+ perfusion medium for 20min. The closed circles and open circles indicate the 4VO-treated rats and sham-control rats, respectively. The data are shown as mean±SD. (Two-way ANOVA and Bonferroni post hoc test; n=6–8) *p<0.05 and **p<0.01. Pathophysiology 2014 21, 309-316DOI: (10.1016/j.pathophys.2014.08.005) Copyright © 2014 Elsevier B.V. Terms and Conditions