Volume 51, Issue 3, Pages (March 2007)

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Volume 51, Issue 3, Pages 825-832 (March 2007) Supraspinal Site of Action for the Inhibition of Ejaculatory Reflex by Dapoxetine Pierre Clément, Jacques Bernabé, Peter Gengo, Pierre Denys, Miguel Laurin, Laurent Alexandre, François Giuliano European Urology Volume 51, Issue 3, Pages 825-832 (March 2007) DOI: 10.1016/j.eururo.2006.10.011 Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 1 Examples of pudendal motoneuron reflex discharges (PMRDs) elicited by bilateral stimulation of the dorsal nerves of the penis (DNP) measured at different times after intrathecal delivery of either saline, dapoxetine 80μg, or 5-HT 100μg. The signal was rectified for analysis purposes, and traces correspond to 60 averaged integrated trials. DNP stimulations are indicated by arrows on the figure. European Urology 2007 51, 825-832DOI: (10.1016/j.eururo.2006.10.011) Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 2 Latency (A) and amplitude (B) of pudendal motoneuron reflex discharges (PMRDs) determined at different times after intrathecal delivery of saline, dapoxetine or serotonin (5-HT), or dapoxetine or saline. Values are expressed as percentage of pretreatment values. Data correspond to the mean±SEM of five rats. Statistics: two-way analysis of variance for repeated measures plus Bonferroni post hoc test; filled symbols indicate significant difference in comparison with saline. European Urology 2007 51, 825-832DOI: (10.1016/j.eururo.2006.10.011) Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 3 Examples of pudendal motoneuron reflex discharges (PMRDs) elicited by bilateral stimulation of the dorsal nerves of the penis (DNP; arrows) measured 5min before (thinner traces) and 60min after (thicker traces) dapoxetine 3mg/kg, intravenously, in rats bilaterally microinjected into lateral paragigantocellular nucleus (LPGi) with either saline or kainic acid 1 d before testing. The signal was rectified for analysis purposes, and traces correspond to 60 averaged integrated trials. European Urology 2007 51, 825-832DOI: (10.1016/j.eururo.2006.10.011) Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 4 Latency (A) and amplitude (B) of pudendal motoneuron reflex discharges (PMRDs) determined 60min after intravenous delivery of 3mg/kg dapoxetine in rats microinjected into lateral paragigantocellular nucleus (LPGi) with either saline or kainic acid 1 d before testing. Values are expressed as percentage of pretreatment values. Data correspond to the mean±SEM of 8 (kainic acid group) and 12 (saline group) rats. Statistics: one-sample t test (hypothetical value: 100%); §p<0.01, §§p<0.001. t test; **p<0.01, ***p<0.001 compared with saline intra-LPGi microinjection. European Urology 2007 51, 825-832DOI: (10.1016/j.eururo.2006.10.011) Copyright © 2006 European Association of Urology Terms and Conditions