International Arab Baccalaureate

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International Arab Baccalaureate 2010 Pilot Sample Outcomes & Items www.EducationalRC.org

Biology www.EducationalRC.org Mutations The nucleotide sequence of an initial transcribed strand of DNA is as follows: DNA: …AGACTTTGTGGATTC… mRNA: …UCUGAAACACCUAAG… Amino acids: …Serine-Glutamic Acid-Threonine-Proline-Lysine… Consider the following DNA mutations : …AGACTTTGTGGATTT… …AGACTTTCTGGATTC… …AGACATTGTGAATTC… …GGACTTTGTGGATTC… …AAGACTTTGTAGATTC… www.EducationalRC.org

Conception: Mutation by Substitution www.EducationalRC.org Outcome: To realize the composition of mutation by substitution. www.EducationalRC.org Question 1: What type(s) of mutation the five alternatives above belong to?

Criterial Thinking: Comparison www.EducationalRC.org Outcome: To compare different mutations based on their transcription and translation. www.EducationalRC.org Question 1: Given the genetic code in the table below, which of the above mutations is silent? AAA Lysine AGA Arginine GUA Valine