Combining Biologics in Inflammatory Bowel Disease and Other Immune Mediated Inflammatory Disorders  Robert P. Hirten, Marietta Iacucci, Shailja Shah, Subrata Ghosh, Jean-Frederic Colombel  Clinical Gastroenterology and Hepatology  Volume 16, Issue 9, Pages 1374-1384 (September 2018) DOI: 10.1016/j.cgh.2018.02.024 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Combinations of biologic agents that have been described in the published literature. Therapeutic agents are connected based on the disease state in which the combination was used with the mechanism of action of each treatment highlighted. APC, antigen-presenting cell; BCMA, B-cell maturation antigen; BLyS, B-lymphocyte stimulator; FcγR, Fc receptors for IgG; ICAM-1, intercellular adhesion molecule-1; IL, interleukin; ILC, innate lymphoid cells; NK, natural killer T cell; TACI, transmembrane activator and calcium modulator and cyclophilin ligand injector; Th, T-helper cell. Clinical Gastroenterology and Hepatology 2018 16, 1374-1384DOI: (10.1016/j.cgh.2018.02.024) Copyright © 2018 AGA Institute Terms and Conditions