A Revision of Billingham’s Tenets: The Central Role of Lymphocyte Migration in Acute Graft-versus-Host Disease Robert Sackstein Biology of Blood and.

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Presentation transcript:

A Revision of Billingham’s Tenets: The Central Role of Lymphocyte Migration in Acute Graft-versus-Host Disease Robert Sackstein Biology of Blood and Marrow Transplantation Volume 12, Issue 1, Pages 2-8 (January 2006) DOI: 10.1016/j.bbmt.2005.09.015 Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Molecular effectors of naive and effector/memory cell homing to lymph node, skin, and gut. Arrows show the direction of homing: Solid black arrows denote cells within efferent lymphatics draining into thoracic duct; Hashed blue arrows denote cells within afferent lymphatics, draining into lymphoid organs; Checkerboard red/white arrows denote cells within the vascular compartment. Enlarged arrows denote physiologic lymphocyte recirculation. Boxes and shading/color identify relevant receptor/ligand pairs for adhesion molecules. Pertinent chemokines and their respective receptors are paired by italics and color. Asterisk on MAdCAM denotes that, when present, specialized sialic acid modifications allow binding to L-selectin (CD62L). Biology of Blood and Marrow Transplantation 2006 12, 2-8DOI: (10.1016/j.bbmt.2005.09.015) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions