Microbiome Medicine: This Changes Everything

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Presentation transcript:

Microbiome Medicine: This Changes Everything John C. Alverdy, MD, FACS Journal of the American College of Surgeons Volume 226, Issue 5, Pages 719-729 (May 2018) DOI: 10.1016/j.jamcollsurg.2018.02.004 Copyright © 2018 American College of Surgeons Terms and Conditions

Figure 1 Multiple lifestyle inputs into the microbiome-host interactome that can shape an individual's immune response to surgical injury. MAP, mitogen-activated protein; NSAIDs, nonsteroidal anti-inflammatory drugs; PAMPs, pathogen-associated molecular patterns; PRR, pathogen-related receptor; SSI, surgical site infection; TNF, tumor necrosis factor. Journal of the American College of Surgeons 2018 226, 719-729DOI: (10.1016/j.jamcollsurg.2018.02.004) Copyright © 2018 American College of Surgeons Terms and Conditions

Figure 2 Proposed mechanism by which the intestinal microbiome influences the host response to surgical injury. (A) Sequence of events by which surgical injury leads to a pathoadaptive response of the microbiome adversely affecting the recovery process. (B) Potential mechanisms by which enhanced recovery programs after surgery (ERAS) lead to a state of molecular détente between the host and its microbiome and promote recovery. MAP, mitogen-activated protein; PAMPs, pathogen-associated molecular patterns; PRR, pathogen-related receptor; SSI, surgical site infection; TNF, tumor necrosis factor. Journal of the American College of Surgeons 2018 226, 719-729DOI: (10.1016/j.jamcollsurg.2018.02.004) Copyright © 2018 American College of Surgeons Terms and Conditions