Turning Reactive Glia into Functional Neurons in the Brain

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Turning Reactive Glia into Functional Neurons in the Brain Jianfeng Lu, Robert A. Bradley, Su-Chun Zhang Cell Stem Cell Volume 14, Issue 2, Pages 133-134 (February 2014) DOI: 10.1016/j.stem.2014.01.010 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Direct Conversion of Reactive Glial Cells to Active Neurons via NeuroD1 Expression Cortical reactive astrocytes and NG2 glial cells in stab-wound and Alzheimer’s disease (5XFAD) mouse models are directly converted to electrophysiologically active neurons by retroviral delivery of NeuroD1 in vivo. Astrocytes are capable of becoming glutaminergic neurons whereas NG2 glial cells are capable of converting into both glutaminergic and GABAergic neurons. Image adapted from Chouchane and Costa (2012). Cell Stem Cell 2014 14, 133-134DOI: (10.1016/j.stem.2014.01.010) Copyright © 2014 Elsevier Inc. Terms and Conditions