Omega 3 Fatty Acids and GPR120

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Omega 3 Fatty Acids and GPR120 Da Young Oh, Jerrold M. Olefsky Cell Metabolism Volume 15, Issue 5, Pages 564-565 (May 2012) DOI: 10.1016/j.cmet.2012.04.009 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 GPR120 Is an ω3-FA Receptor/Sensor, and Loss of Function Leads to Obesity and Insulin Resistance A small fraction (∼3%) of obese subjects carry a loss-of-function, nonsynonymous GPR120 variant (R270H) that exhibits impaired intrinsic signaling properties and inhibits ω3-FA stimulation of WT GPR120. In European populations, this variant is associated with increased risk for obesity and insulin resistance, and high-fat-fed GPR120 KO mice also develop obesity and insulin resistance. Cell Metabolism 2012 15, 564-565DOI: (10.1016/j.cmet.2012.04.009) Copyright © 2012 Elsevier Inc. Terms and Conditions