Estimating the Glomerular Filtration Rate in Obese Adult Patients for Drug Dosing  Manjunath P. Pai  Advances in Chronic Kidney Disease  Volume 17, Issue 5, Pages e53-e62 (September 2010) DOI: 10.1053/j.ackd.2010.05.010 Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 The fractional change in tissue/organ weight as a function of total body weight in male subjects between 50 kg and 250 kg, using data from a 50-kg subject as the reference.32 Advances in Chronic Kidney Disease 2010 17, e53-e62DOI: (10.1053/j.ackd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 The fractional change in alternate body size (weight) descriptors as a function of total body weight in male subjects between 50 kg and 250 kg, using data from a 50-kg, 176-cm subject as the reference.17,34 Abbreviations: IBW, ideal body weight; ABW, adjusted body weight; LBW1976, lean body weight published in 1976; FFW, fat free weight; PNWT, fat free weight; LBW2005, lean body weight published in 2005. Advances in Chronic Kidney Disease 2010 17, e53-e62DOI: (10.1053/j.ackd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 The fractional change in alternate body size (body surface area and lean body weight) descriptors as a function of total body weight in subjects between 50 kg and 250 kg, using data from a 50-kg, 176-cm male subject as the reference.17,25 Abbreviations: BSA_DD, Body surface area using the DuBois and DuBois equation; BSA_GG, BSA using the Gehan and George equation; BSA_H, BSA using the Haycock and colleagues equation; (BSA_M)BSA using the Mosteller equation; BSA_LL, BSA using the Livingstone and Lee; LBW2005, lean body weight published in 2005. Advances in Chronic Kidney Disease 2010 17, e53-e62DOI: (10.1053/j.ackd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Residual versus estimated glomerular filtration rate or creatinine clearance when comparing the Modification of Diet in Renal Disease (isotopic dilution mass spectrometry traceable) equations transformed with BSA_M (A) and the CG_LBW (B) relative to measured 24-hour CLcr in morbidly obese subjects.21 Advances in Chronic Kidney Disease 2010 17, e53-e62DOI: (10.1053/j.ackd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions