Video-Assisted Thoracoscopic Surgery Versus Thoracotomy Lymph Node Dissection in Clinical Stage I Lung Cancer: A Meta-Analysis and System Review Wenxiong.

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Video-Assisted Thoracoscopic Surgery Versus Thoracotomy Lymph Node Dissection in Clinical Stage I Lung Cancer: A Meta-Analysis and System Review Wenxiong Zhang, MD, Yiping Wei, MD, Han Jiang, MM, Jianjun Xu, MM, Dongliang Yu, MM The Annals of Thoracic Surgery Volume 101, Issue 6, Pages 2417-2424 (June 2016) DOI: 10.1016/j.athoracsur.2015.11.055 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Flow diagram of screened and included papers. (LNN = lymph node number; LNS = lymph node station number; SD = standard deviation; VATS = video-assisted thoracoscopic surgery.) The Annals of Thoracic Surgery 2016 101, 2417-2424DOI: (10.1016/j.athoracsur.2015.11.055) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Forest plot of the mean difference in (A) total lymph node number and (B) lymph node station number in the video-assisted thoracoscopic surgery (VATS) group vs the thoracotomy (Open) group. The horizontal lines represent the 95% confidence interval (CI). The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The diamond indicates the weighted mean difference and the lateral tips of the diamond indicate the associated 95% CI. (IV = inverse variance; SD = standard deviation.) The Annals of Thoracic Surgery 2016 101, 2417-2424DOI: (10.1016/j.athoracsur.2015.11.055) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Forest plot of the mean difference in (A) N2 lymph node number and (B) lymph node station number in the video-assisted thoracoscopic surgery (VATS) group vs the thoracotomy (Open) group. The horizontal lines represent the 95% confidence interval (CI). The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The diamond indicates the weighted mean difference and the lateral tips of the diamond indicate the associated 95% CI. (IV = inverse variance; SD = standard deviation.) The Annals of Thoracic Surgery 2016 101, 2417-2424DOI: (10.1016/j.athoracsur.2015.11.055) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Forest plot of the mean difference in N1 lymph node number in the video-assisted thoracoscopic surgery (VATS) group vs the thoracotomy (Open) group. The horizontal lines represent the 95% confidence interval (CI). The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The diamond indicates the weighted mean difference and the lateral tips of the diamond indicate the associated 95% CI. (IV = inverse variance; SD = standard deviation.) The Annals of Thoracic Surgery 2016 101, 2417-2424DOI: (10.1016/j.athoracsur.2015.11.055) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Forest plot of the mean difference in (A) left-side and (B) right-side lymph node number in the video-assisted thoracoscopic surgery (VATS) group vs the thoracotomy (Open) group. The horizontal lines represent the 95% confidence interval (CI). The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The diamond indicates the weighted mean difference and the lateral tips of the diamond indicate the associated 95% CI. (IV = inverse variance; SD = standard deviation.) The Annals of Thoracic Surgery 2016 101, 2417-2424DOI: (10.1016/j.athoracsur.2015.11.055) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Funnel plot of the mean difference (MD) in total lymph node number in the video-assisted thoracoscopic surgery group versus the thoracotomy group. (SE = standard error.) The Annals of Thoracic Surgery 2016 101, 2417-2424DOI: (10.1016/j.athoracsur.2015.11.055) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions