Reproducibility and Complications in Gene Searches: Linkage on Chromosome 6, Heterogeneity, Association, and Maternal Inheritance in Juvenile Myoclonic.

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Reproducibility and Complications in Gene Searches: Linkage on Chromosome 6, Heterogeneity, Association, and Maternal Inheritance in Juvenile Myoclonic Epilepsy  David A. Greenberg, Martina Durner, Mehdi Keddache, Shlomo Shinnar, Stanley R. Resor, Solomon L. Moshe, David Rosenbaum, Jeffrey Cohen, Cynthia Harden, Harriet Kang, Sibylle Wallace, Daniel Luciano, Karen Ballaban-Gil, Livia Tomasini, Guilian Zhou, Irene Klotz, Elisa Dicker  The American Journal of Human Genetics  Volume 66, Issue 2, Pages 508-516 (February 2000) DOI: 10.1086/302763 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 Multipoint LOD scores for JME on chromosome 6, showing curves both with and without the assumption of heterogeneity. The American Journal of Human Genetics 2000 66, 508-516DOI: (10.1086/302763) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 2 Pedigree of a family with epilepsy, showing a recombinant (box) between DQ and DP, suggesting that EJM1 lies distal to DP. The American Journal of Human Genetics 2000 66, 508-516DOI: (10.1086/302763) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 3 Multipoint linkage analysis for families in which the index patient was CA.RING3.3+ or CA.RING3.3− The American Journal of Human Genetics 2000 66, 508-516DOI: (10.1086/302763) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

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