European Urology Oncology Extraprostatic Extension in Core Biopsies Epitomizes High-risk but Locally Treatable Prostate Cancer  Hanan Goldberg, Abu-Hijlih Ramiz, Rachel Glicksman, Noelia S. Salgado, Thenappan Chandrasekar, Zachary Klaassen, Christopher J.D. Wallis, Ali Hosni, Fabio Ynoe Moraes, Sangeet Ghai, Girish S. Kulkarni, Robert J. Hamilton, Nathan Perlis, Ants Toi, Peter Chung, Andrew Evans, Theo van der Kwast, Antonio Finelli, Neil Fleshner, Alejandro Berlin  European Urology Oncology  DOI: 10.1016/j.euo.2018.05.003 Copyright © 2018 Terms and Conditions

Fig. 1 Tumor extending into periprostatic fat on needle core biopsy and final radical prostatectomy specimen. (A) Low-magnification overview showing a prostate core biopsy that is extensively involved by adenocarcinoma. The box indicates the location of periprostatic fat on the end of the core. (B) Higher-magnification image of the box shown in A highlighting adenocarcinoma admixed with desmoplastic stroma and fat. (C) Low-magnification overview of a section from the right posterior quadrant collected during radical prostatectomy performed on the same patient. This section corresponds to the quadrant from which the biopsy was obtained. Note the lack of a well-defined histologic capsule between the prostate parenchyma and the extraprostatic soft tissue. (D) Higher-magnification image confirming the prostate biopsy diagnosis of extraprostatic extension, as indicated by adenocarcinoma in the plane of periprostatic fat. In addition, The presence of tumor showing perineural invasion within the periprostatic fat is evident (arrow). European Urology Oncology DOI: (10.1016/j.euo.2018.05.003) Copyright © 2018 Terms and Conditions

Fig. 2 (A) Metastasis-free survival and (B) biochemical recurrence-free survival in the entire cohort. (C) Metastasis-free survival and (D) biochemical recurrence-free survival stratified by treatment group (radical prostatectomy and radiotherapy). European Urology Oncology DOI: (10.1016/j.euo.2018.05.003) Copyright © 2018 Terms and Conditions