Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity Diana Chessman,

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Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity Diana Chessman, Lyudmila Kostenko, Tessa Lethborg, Anthony W. Purcell, Nicholas A. Williamson, Zhenjun Chen, Lars Kjer-Nielsen, Nicole A. Mifsud, Brian D. Tait, Rhonda Holdsworth, Coral Ann Almeida, David Nolan, Whitney A. Macdonald, Julia K. Archbold, Anthony D. Kellerher, Debbie Marriott, Simon Mallal, Mandvi Bharadwaj, Jamie Rossjohn, James McCluskey Immunity Volume 29, Issue 1, (July 2008) DOI: 10.1016/j.immuni.2008.06.002 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 5 Fine Specificity of Abacavir-Specific CD8+ T Cells Determined by the Antigen-Binding F Pocket Abacavir-specific T cells were raised in vitro from a HLA-B∗5701-positive donor and then restimulated with the C1R cell lines expressing HLA-B∗5701, HLAB∗5703, the HLA-B∗5703 back mutant 114Asp→Asn, or the HLA-B∗5703 back mutant 116Ser→Tyr. Flow histograms of gated lymphocytes are shown stained for intracellular IFNγ (y axis) and CD8 (x axis). The percentage of responding IFNγ+ CD8+ T cells as a fraction of total gated lymphocytes is shown in the upper-right-hand quadrants. Differences between the peptide-binding clefts of HLA-B∗5701, HLA-B∗5703, and HLA-B∗5703 back mutants are indicated with filled circles, and the amino acid substitutions from B∗5701 are given above each illustration. Immunity 2008 29, DOI: (10.1016/j.immuni.2008.06.002) Copyright © 2008 Elsevier Inc. Terms and Conditions