Stem Cells Show Parental Control

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Stem Cells Show Parental Control Peggy Myung, Valentina Greco Cell Volume 162, Issue 3, Pages 476-477 (July 2015) DOI: 10.1016/j.cell.2015.06.030 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Parental Stem Cells Regulate Progeny Cell Fate in Airway Epithelium by Notch Signaling (A) The proximal airway epithelium houses basal stem cells that can differentiate into secretory cells and post-mitotic ciliated cells. Basal cells express Notch ligands that activate Notch2 receptors on secretory cells that are required for their maintenance (forward regulation). In the absence of basal cell Notch ligands or Notch2 activation in secretory cells, secretory cells covert into ciliated cells. (B) When basal stem cells are ablated, secretory cells can dedifferentiate into basal cells or convert into ciliated cells, presumably due to a loss of notch ligand from basal cells. Cell 2015 162, 476-477DOI: (10.1016/j.cell.2015.06.030) Copyright © 2015 Elsevier Inc. Terms and Conditions