C.-P. Kuo, C.-L. Wu, H.-T. Ho, C.G. Chen, S.-I. Liu, Y.-T. Lu

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Detection of cytomegalovirus reactivation in cancer patients receiving chemotherapy C.-P. Kuo, C.-L. Wu, H.-T. Ho, C.G. Chen, S.-I. Liu, Y.-T. Lu Clinical Microbiology and Infection Volume 14, Issue 3, Pages 221-227 (March 2008) DOI: 10.1111/j.1469-0691.2007.01895.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Mean cytomegalovirus (CMV) counts in leukocytes as determined by real-time quantitative PCR at baseline and after each course of chemotherapy. Ten of 15 participants had undetectable virus at baseline before starting chemotherapy. The peak recorded viral load was found after the third course of chemotherapy, with ten patients reaching a maximum viral load after the third to fourth course of chemotherapy. *p <0.05, course 3 compared to courses 0, 1, 2, 4, 5 and 6. Clinical Microbiology and Infection 2008 14, 221-227DOI: (10.1111/j.1469-0691.2007.01895.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Mean cytomegalovirus (CMV)-specific IgG in baseline blood samples and after each course of chemotherapy. The recorded anti-CMV IgG titre of nine patients peaked after the recorded viral load peak. Clinical Microbiology and Infection 2008 14, 221-227DOI: (10.1111/j.1469-0691.2007.01895.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 Mean tumour necrosis factor (TNF)-α plasma levels at baseline and after each course of chemotherapy. The level peaked in three patients at the same time as the recorded peak viral load, and in ten patients after the recorded viral load peak. Clinical Microbiology and Infection 2008 14, 221-227DOI: (10.1111/j.1469-0691.2007.01895.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 4 Mean interferon (IFN)-γ plasma levels at baseline and after each course of chemotherapy. Seven (46.7%) participants had the highest levels of IFN-γ after the recorded viral load peak. Clinical Microbiology and Infection 2008 14, 221-227DOI: (10.1111/j.1469-0691.2007.01895.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 5 Mean combined score for cytomegalovirus-associated symptoms and laboratory findings at baseline and after each course of chemotherapy. The peak score preceded the recorded peak number of viral particles. *p <0.05, course 2 compared to courses 0, 1, 4, 5 and 6. p <0.05, course 3 compared to courses 0, 1, 4, 5 and 6. Clinical Microbiology and Infection 2008 14, 221-227DOI: (10.1111/j.1469-0691.2007.01895.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions