Fertility after bilateral uterine artery embolization in a sheep model

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Presentation transcript:

Fertility after bilateral uterine artery embolization in a sheep model Alexandre Laurent, M.D., Ph.D., Jean-Pierre Pelage, M.D., Ph.D., Michel Wassef, M.D., Jacques Martal, Vet.D. Fertility and Sterility Volume 89, Issue 5, Pages 1371-1383 (May 2008) DOI: 10.1016/j.fertnstert.2007.03.058 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Experimental design of the study. Briefly, after a first synchronization of all ewes, embolization was performed. Ewes were naturally inseminated under controlled estrus conditions, and a hormonal follow-up allowed us to diagnose ovulation, gestation, and abortion. In cases of unsuccessful pregnancy after the first trial, two other trials were scheduled. Fertility and Sterility 2008 89, 1371-1383DOI: (10.1016/j.fertnstert.2007.03.058) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Progesterone (P4) and PSP profiles of ewes in the complete-pregnancy group, the abortion group, and the nonpregnant group. (A) The progesterone (P) profiles of the ewes in the complete pregnancy group and the nonpregnant group are significantly different from those on GD18 (P<.0001, Mann-Whitney), whereas the P4 profiles of the ewes in the complete-pregnancy group and the abortion group are significantly different from those on GD111 (P<.001, Mann-Whitney). (B) The PSP profiles of the ewes in the complete-pregnancy group and abortion group are significantly different from GD33 (P<.001, Mann-Whitney). Levels of PSP in nonpregnant ewes are close to null throughout the hormonal follow-up. Placental-specific protein and P4 are expressed as mean ± SD. GD0 = day of insemination; GD137 = 137th day of gestation; n = number of animals. Fertility and Sterility 2008 89, 1371-1383DOI: (10.1016/j.fertnstert.2007.03.058) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Centiles of the body weight of newborns in the three treatment groups. Dotted lines represent the 10th to 90th centiles of the body weight of newborns in the control group. The curves of body weight of newborns are nearly identical in the control and TGMS groups, whereas most of newborns in the PVA group have a body weight of ≤10th percentile of control (i.e., ≤2.5 kg). BW = body weight. Fertility and Sterility 2008 89, 1371-1383DOI: (10.1016/j.fertnstert.2007.03.058) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Fertility rate in the three treatment groups. Contrary to the case of TGMS-embolized animals, PVA-embolized animals exhibit a significant decrease in their fertility rate compared with controls. n = number of animals. Fertility and Sterility 2008 89, 1371-1383DOI: (10.1016/j.fertnstert.2007.03.058) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 5 Rates of live gestation, nongestation, and abortion. There are more numerous complete pregnancies in the control group than in the embolized group. The gestation rate is significantly decreased in PVA-embolized ewes, compared with in controls. The gestation rate is not significantly decreased in TGMS-embolized ewes, compared with in controls. Compared with controls, the rate of nongestation is significantly higher in all embolized animals, whatever the embolic agent. The rate of abortion is not significantly different among the three groups. Fertility and Sterility 2008 89, 1371-1383DOI: (10.1016/j.fertnstert.2007.03.058) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions