The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology Mate Kiss, Zsolt Czimmerer,

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Presentation transcript:

The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology Mate Kiss, Zsolt Czimmerer, MSc, Laszlo Nagy, MD, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 2, Pages 264-286 (August 2013) DOI: 10.1016/j.jaci.2013.05.044 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Pathways of lipid metabolism providing ligands for retinoid receptors, PPARγ, LXR, and VDR. The cellular isoprenoid pool is one of the main sources of nuclear receptor ligands. Some intermediates are omitted for clarity. Journal of Allergy and Clinical Immunology 2013 132, 264-286DOI: (10.1016/j.jaci.2013.05.044) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Domain structure of nuclear receptors. Colors on the domain structure above correspond to the identically colored domains on the schematic 3-dimensional structure below. AF-1, Ligand-independent activation function; AF-2, ligand-dependent activation function; DBD, DNA-binding domain, hinge region. Journal of Allergy and Clinical Immunology 2013 132, 264-286DOI: (10.1016/j.jaci.2013.05.044) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Basic mechanisms of nuclear receptor action. A, Ligand-independent corepressor recruitment and gene repression. B, Ligand-dependent coactivator recruitment and gene activation. C, Ligand-dependent corepressor recruitment and gene repression. D, Ligand-dependent transrepression of gene activation mediated by other transcription factors. Journal of Allergy and Clinical Immunology 2013 132, 264-286DOI: (10.1016/j.jaci.2013.05.044) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Metabolic and immune functions of macrophages influenced by retinoid receptors, PPARγ, LXR, and VDR. A positive effect of nuclear receptor ligand on a macrophage function is indicated by green, a negative effect is indicated by red, and empty cells indicate that insufficient or no data are available regarding the effect of ligand on that particular function. LDL, Low-density lipoprotein. Journal of Allergy and Clinical Immunology 2013 132, 264-286DOI: (10.1016/j.jaci.2013.05.044) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Metabolic and immune functions of DCs influenced by retinoid receptors, PPARγ, LXR, and VDR. A positive effect of nuclear receptor ligand on DC function is indicated by green, negative effect is indicated by red, both green and red indicate that available data show contradiction, and empty cells indicate that insufficient or no data are available regarding the effect of ligand on that particular function. Journal of Allergy and Clinical Immunology 2013 132, 264-286DOI: (10.1016/j.jaci.2013.05.044) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions