Increased TGF-β2 in severe asthma with eosinophilia

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Increased TGF-β2 in severe asthma with eosinophilia Silvana Balzar, MD, Hong Wei Chu, MD, Phillip Silkoff, MD, Meghan Cundall, MS, John B. Trudeau, BS, Matthew Strand, PhD, Sally Wenzel, MD Journal of Allergy and Clinical Immunology Volume 115, Issue 1, Pages 110-117 (January 2005) DOI: 10.1016/j.jaci.2004.09.034 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Numbers of positive cells (filled circles) and relative tissue mRNA expression (bars with SEM) for (A) TGF-β1, (B) TGF-β2, and (C) TGF-β3+ cells in airway submucosa of normal subjects, subjects with mild asthma, and subjects with severe asthma with and without persistent eosinophilia. ∗P < .05 for pairwise comparisons. Journal of Allergy and Clinical Immunology 2005 115, 110-117DOI: (10.1016/j.jaci.2004.09.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Double immunofluorescence of airway tissue colocalizes ∼80% of TGF-β2+ cells (red) with eosinophils (green) in an eosinophil+ subject with severe asthma (A). There are no TGF-β2+ eosinophils (hollow arrows) in a subject with mild asthma (B) or a normal control (C). Filled arrows point at the epithelial layer (epi) and SBM. Original magnification 200× for A, 100× for B and C. Journal of Allergy and Clinical Immunology 2005 115, 110-117DOI: (10.1016/j.jaci.2004.09.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Representative photographs of (A) TGF-βRI and (B) TGF-βRII immunostaining in airway smooth muscle. Original magnification 100×. Journal of Allergy and Clinical Immunology 2005 115, 110-117DOI: (10.1016/j.jaci.2004.09.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Immunostaining for CTGF in endobronchial biopsy tissue of a normal control (A) and a subject with severe asthma (B). Original magnification 100×. Journal of Allergy and Clinical Immunology 2005 115, 110-117DOI: (10.1016/j.jaci.2004.09.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 Percentages of smooth muscle area stained for (A) TGF-βRI, (B) TGF-βRII, and (C) CTGF in airways of normal subjects, subjects with mild asthma, and subjects with severe asthma with and without persistent eosinophilia. ∗P < .05 for pairwise comparison. Journal of Allergy and Clinical Immunology 2005 115, 110-117DOI: (10.1016/j.jaci.2004.09.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 6 TIMP-1 levels in BAL fluid (A) and SBM thickness (B) from normal subjects, subjects with mild asthma, and subjects with severe asthma with and without persistent eosinophilia. ∗P < .05 for pairwise comparison; †P < .05 compared with all other groups. Journal of Allergy and Clinical Immunology 2005 115, 110-117DOI: (10.1016/j.jaci.2004.09.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions