Flow cytometric testing of susceptibilities of Mycobacterium avium to amikacin, ciprofloxacin, clarithromycin and rifabutin in 24 hours R.M. Vena, E.L.

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Presentation transcript:

Flow cytometric testing of susceptibilities of Mycobacterium avium to amikacin, ciprofloxacin, clarithromycin and rifabutin in 24 hours R.M. Vena, E.L. Munson, D.J. DeCoster, C.L. Croke, D.B. Fett, S.M. Callister, R.F. Schell Clinical Microbiology and Infection Volume 6, Issue 7, Pages 366-373 (July 2000) DOI: 10.1046/j.1469-0691.2000.00100.x Copyright © 2000 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 Number of M. avium cells (events)/mL detected by flow cytometry with or without (▪) exposure to 0.01 (▴), 0.5 (•), 2.0 (⋄) or 8.0 (□) mg/L of amikacin (a), clarithromycin (b), ciprofloxacin (c), or rifabutin (d) for 24 or 48h. The experimental error was ±0.26, 0.24, 0.15 and 0.11 for amikacin (a), clarithromycin (b), ciprofloxacin (c), and rifabutin (d), respectively. Clinical Microbiology and Infection 2000 6, 366-373DOI: (10.1046/j.1469-0691.2000.00100.x) Copyright © 2000 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 Susceptibility index values of different isolates of M. avium (⋄=768, ▪=244, •=175 for (a); ⋄=825, ▪=510, •=141 for (b); ⋄=730, ▪=250, •=141 for (c); and ⋄=455, ▪=244, •=266 for (d), with or without exposure to selected concentrations of amikacin (a), clarithromycin (b), ciprofloxacin (c), or rifabutin (d) for 24h. Clinical Microbiology and Infection 2000 6, 366-373DOI: (10.1046/j.1469-0691.2000.00100.x) Copyright © 2000 European Society of Clinical Infectious Diseases Terms and Conditions