Figure 7 European Society of Cardiology 2016 guidelines for the treatment of patients with symptomatic HFrEF Reproduced from Ponikowski, P., et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur. Heart J. 2016; 37 (27): 2129–2200. doi: 10.1093/eurheartj/ehw128,. Reproduced with permission of Oxford University Press on behalf of the European Society of Cardiology. Please visit: www.escardio.org Bloom, M. W. et al. (2017) Heart failure with reduced ejection fraction Nat. Rev. Dis. Primers doi:10.1038/nrdp.2017.58