Haemodilution-induced profibrinolytic state is mitigated by fresh-frozen plasma: implications for early haemostatic intervention in massive haemorrhage

Slides:

Advertisements

Similar presentations

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Advertisements

C. Solomon, R.E. Collis, P.W. Collins British Journal of Anaesthesia

P.A. Bothma, C.J. Schlimp British Journal of Anaesthesia

Assessment of standard laboratory tests and rotational thromboelastometry for the prediction of postoperative bleeding in liver transplantation T.M.

Haemodilution-induced changes in coagulation and effects of haemostatic components under flow conditions† S. Ogawa, T. Ohnishi, K. Hosokawa, F. Szlam,

Human factors in anaesthesia: lessons from aviation

Norepinephrine and ephedrine do not counteract the increase in cutaneous microcirculation induced by spinal anaesthesia J.-P.H. Lecoq, J.-F. Brichant,

Reversal by the specific antidote, idarucizumab, of elevated dabigatran exposure in a patient with rectal perforation and paralytic ileus C. Thorborg,

G Weiss, S Lison, M Spannagl, B Heindl British Journal of Anaesthesia

Why is the surgical high-risk patient still at risk?

Supplemental oxygen and surgical site infection: getting to the truth

Rotation thromboelastometry detects thrombocytopenia and hypofibrinogenaemia during orthotopic liver transplantation S. Roullet, J. Pillot, G. Freyburger,

K.-Y. Ho, W Tay, M.-C. Yeo, H Liu, S.-J. Yeo, S.-L. Chia, N.-N. Lo

Autonomic nervous system state: the effect of general anaesthesia and bilateral tonsillectomy after unilateral infiltration of lidocaine† M.P.J. Paloheimo,

Effects of colloid and crystalloid solutions on endogenous activation of fibrinolysis and resistance of polymerized fibrin to recombinant tissue plasminogen.

Heat stroke: implications for critical care and anaesthesia

Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery:

Differential effects of lidocaine and remifentanil on response to the tracheal tube during emergence from general anaesthesia J.H. Lee, B.-N. Koo, J.-J.

Efficacy of fibrinogen and prothrombin complex concentrate used to reverse dilutional coagulopathy—a porcine model D. Fries, T. Haas, A. Klingler, W.

A.F. Kopman, C.A. Lien, M Naguib British Journal of Anaesthesia

D. Fries, A. Krismer, A. Klingler, W. Streif, G. Klima, V. Wenzel, T

Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage: OBS2, an observational study P.W. Collins, R. Cannings-John, D. Bruynseels,

Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements E. Schaden, O. Kimberger, P. Kraincuk, D.M.

A different use of visual analytic techniques in anaesthetics

Perioperative factor concentrate therapy

Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate P.W. Collins, C. Solomon, K.

A. J. Cronin, N. M. Aucutt-Walter, T Budinetz, C. P. Bonafide, N. A

M Ranucci, E Baryshnikova British Journal of Anaesthesia

Ex vivo reversal of effects of rivaroxaban evaluated using thromboelastometry and thrombin generation assay B. Schenk, P. Würtinger, W. Streif, W. Sturm,

Effects of tirofiban on haemostatic activation in vitro†

Incidence of postoperative nausea and vomiting after paediatric strabismus surgery with sevoflurane or remifentanil–sevoflurane A.Y. Oh, J.H. Kim, J.W.

T. Iirola, S. Vilo, R. Aantaa, M. Wendelin-Saarenhovi, P. J

Anaesthetists’ non-technical skills

Early or late fresh frozen plasma administration in newborns and small infants undergoing cardiac surgery: the APPEAR randomized trial P. Bianchi, M.

J.H. Levy, M. Gottge, F. Szlam, R. Zaffer, C. McCall

Coagulopathy and blood component transfusion in trauma

Usefulness of spirometry in air leak evaluation during laparoscopic surgery in an obese patient with laryngeal mask airway Supreme™ M Carron, U Freo,

Successful intubation using retrograde trans-tracheal illumination after laryngoscope light source failure J Hudson, M Vu, E Vu British Journal of Anaesthesia

Role of fibrinogen in trauma-induced coagulopathy

In vitro effects of antihypertensive drugs on thromboxane agonist (U46619)-induced vasoconstriction in human internal mammary artery Tanaka K.A. , Szlam.

Bispectral index is related to the spread of spinal sensory block in patients with combined spinal and general anaesthesia R Iida, K Iwasaki, J Kato,

Thromboelastometry (ROTEM®) in children: age-related reference ranges and correlations with standard coagulation tests E Oswald, B Stalzer, E Heitz,

Volatile anaesthetics and positive pressure ventilation reduce left atrial performance: a transthoracic echocardiographic study in young healthy adults

Prothrombin complex concentrate mitigates diffuse bleeding after cardiopulmonary bypass in a porcine model F Kaspereit, S Hoffmann, I Pragst, G Dickneite

Effects of protamine and heparin can be detected and easily differentiated by modified thrombelastography (Rotem®): an in vitro study M Mittermayr, J.

Protamine Enhances Fibrinolysis by Decreasing Clot Strength: Role of Tissue Factor- Initiated Thrombin Generation Vance G. Nielsen, MD The Annals of.

Takotsubo cardiomyopathy and anaesthesia

Recombinant factor VIIa reduces bleeding after blunt liver injury in coagulopathic, hypofibrinogenaemic pigs O Grottke, T Braunschweig, L Zimmermann,

Pain assessment in conscious healthy volunteers: a crossover study evaluating the analgesia/nociception index Q. Yan, H.Y. An, Y. Feng British Journal.

N. A. Guzzetta, F. Szlam, A. S. Kiser, J. D. Fernandez, A. D. Szlam, T

Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery C. Solomon,

Different effects of sevoflurane, desflurane, and isoflurane on early and late left ventricular diastolic function in young healthy adults† D. Bolliger,

Activated thrombelastogram in neonates and infants with complex congenital heart disease in comparison with healthy children B. Haizinger, H. Gombotz,

Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model G. Dickneite, I. Pragst British.

Differential impacts of modes of anaesthesia on the risk of stroke among preeclamptic women who undergo Caesarean delivery: a population-based study

Self-citation in anaesthesia and critical care journals: introducing a flat tax G Landoni, M Pieri, D Nicolotti, S Silvetti, P Landoni, P Silvani, M John,

Effect of dexamethasone in combination with caudal analgesia on postoperative pain control in day-case paediatric orchiopexy J.-Y. Hong, S.W. Han, W.O.

G.B. Drummond, B. Lafferty British Journal of Anaesthesia

J Lee, S Gupta, C Price, A.P. Baranowski

Relative concentrations of haemostatic factors and cytokines in solvent/detergent- treated and fresh-frozen plasma O.M. Theusinger, W. Baulig, B. Seifert,

Chronic widespread pain, including fibromyalgia: a pathway for care developed by the British Pain Society J. Lee, B. Ellis, C. Price, A.P. Baranowski

Peripheral venous pressure as an alternative to central venous pressure in patients undergoing laparoscopic colorectal surgery S.H. Kim, S.Y. Park, J.

Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations C. Fenger-Eriksen, M. Lindberg-Larsen,

Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients A. Levrat, A. Gros, L. Rugeri, K. Inaba, B. Floccard,

Fibrinogen plasma concentration before delivery is not associated with postpartum haemorrhage: a prospective observational study O. Karlsson, A. Jeppsson,

Grand mal convulsion and plasma concentrations after intravascular injection of ropivacaine for axillary brachial plexus blockade M. Mu¨ller, R.J. Litz,

Influence of shoulder position on central venous catheter tip location during infraclavicular subclavian approach M Kang, H.-G. Ryu, I.-S. Son, J.-H.

Effect of body mass index on the ED50 volume of bupivacaine 0

Influence of acute normovolaemic haemodilution on the dose–response relationship and time course of action of cisatracurium besylate A.A. Dahaba, G.

Wee L. , Barron J. , Toye R. British Journal of Anaesthesia

Presentation transcript:

Haemodilution-induced profibrinolytic state is mitigated by fresh-frozen plasma: implications for early haemostatic intervention in massive haemorrhage D. Bolliger, F. Szlam, J.H. Levy, R.J. Molinaro, K.A. Tanaka British Journal of Anaesthesia Volume 104, Issue 3, Pages 318-325 (March 2010) DOI: 10.1093/bja/aeq001 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 Thromboelastometric parameters: CT, angle, MCF, LOT, and LT are depicted. For more explanation see text. British Journal of Anaesthesia 2010 104, 318-325DOI: (10.1093/bja/aeq001) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 Representative thrombin generation curve in the PPP of a healthy volunteer after in vitro dilution: thrombin generation curves cannot be differentiated to baseline after dilution with FFP to 40% and 15%, whereas peak thrombin generation decreases dilution-dependently due to reduced concentration of procoagulant clotting factor. After dilution with saline, thrombin activity is sustained longer due to reduced antithrombin activity. British Journal of Anaesthesia 2010 104, 318-325DOI: (10.1093/bja/aeq001) Copyright © 2010 The Author(s) Terms and Conditions

Fig 3 Thromboelastometric lysis parameters in the in vitro model of dilution: LOT and LT were significantly lower after dilution with saline compared with the corresponding dilution with FFP (*P<0.001). LOT and LT were comparable with baseline after dilution to 40% with FFP and decrease only after further dilution. Adding fibrinogen to the sample diluted with saline to 15% did not significantly increase LOT and LT (§P=1.000). British Journal of Anaesthesia 2010 104, 318-325DOI: (10.1093/bja/aeq001) Copyright © 2010 The Author(s) Terms and Conditions