Volume 119, Issue 4, Pages (October 2000)

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Volume 119, Issue 4, Pages 949-960 (October 2000) The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals Frédéric Carrière, Christophe Renou, Véronique Lopez, Josiane de Caro, Francine Ferrato, Hans Lengsfeld, Alain de Caro, René Laugier, Robert Verger Gastroenterology Volume 119, Issue 4, Pages 949-960 (October 2000) DOI: 10.1053/gast.2000.18140 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Tubes for the in vivo study of meal fat digestion in healthy volunteers. (A) Gastric and 4-lumen duodenal tubes used with the liquid test meal to collect gastric, postpyloric, and duodenal samples. The same duodenal tube was also used with the solid test meal for the postpyloric collection of gastric contents. (B) Gastric and 2-lumen duodenal tubes used with the solid test meal to collect gastric and duodenal samples. Gastroenterology 2000 119, 949-960DOI: (10.1053/gast.2000.18140) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Stability of HGL and HPL in the course of in vitro experiments. Samples were collected at various time intervals from the reaction vessel in which the meal was mixed with gastric and pancreatic juices or purified lipases, and the residual lipase activity on tributyrin was measured. The mass concentration in active lipase (μg/mL) was deduced from the known specific activities of HGL and HPL on tributyrin and plotted as a function of time. (A) HGL mixed with the liquid test meal; (B) HGL mixed with the solid test meal; (C) HPL mixed with the liquid test meal; (D) HPL mixed with the solid test meal. Gastroenterology 2000 119, 949-960DOI: (10.1053/gast.2000.18140) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 FFA release as a function of time during in vitro experiments. Samples were collected at various times from the reaction vessel in which the meal was mixed with juices or purified lipases, and the FFA levels were measured by thin-layer chromatography. (A) Liquid test meal mixed with digestive juices or with purified lipases; (B) solid test meal with digestive juices or with purified lipases. Gastroenterology 2000 119, 949-960DOI: (10.1053/gast.2000.18140) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 4 In vivo activity of HGL on the liquid test meal TGs. (A) HGL levels (μg/mL) in postpyloric contents as a function of time after meal ingestion; (C) FFA levels (μmol/mL) in postpyloric contents as a function of time; (B) pH values of postpyloric contents as a function of time; (D) HGL specific activity in postpyloric contents as a function of time. Gastroenterology 2000 119, 949-960DOI: (10.1053/gast.2000.18140) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 5 In vivo activity of HGL on the solid test meal TGs. (A) HGL levels (μg/mL) in postpyloric contents as a function of time after meal ingestion; (C) FFA levels (μmol/mL) in postpyloric contents as a function of time; (B) pH values of postpyloric contents as a function of time; (D) HGL specific activity in postpyloric contents as a function of time. Gastroenterology 2000 119, 949-960DOI: (10.1053/gast.2000.18140) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 6 In vivo activity of HPL on liquid test meal TGs. (A) HPL levels (μg/mL) in duodenal contents as a function of time after meal ingestion; (C) FFA levels (μmol/mL) in duodenal contents as a function of time; (B) pH values of duodenal contents as a function of time; (D) HPL specific activity in duodenal contents as a function of time. Gastroenterology 2000 119, 949-960DOI: (10.1053/gast.2000.18140) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 7 In vivo activity of HPL on the solid test meal TGs. (A) HPL levels (μg/mL) in duodenal contents as a function of time after meal ingestion; (C) FFA levels (μmol/mL) in duodenal contents as a function of time; (B) pH values of duodenal contents as a function of time; (D) HPL specific activity in duodenal contents as a function of time. Gastroenterology 2000 119, 949-960DOI: (10.1053/gast.2000.18140) Copyright © 2000 American Gastroenterological Association Terms and Conditions