Volume 6, Issue 11, (November 2009)

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Volume 6, Issue 11, (November 2009) Erratum Heart Rhythm Volume 6, Issue 11, (November 2009) DOI: 10.1016/j.hrthm.2009.09.027 Copyright © 2009 Terms and Conditions

Figure 4 Endocardial tissue was studied in vitro. Zero line, voltage, and time calibration are indicated. A: Isoproterenol (5 × 10−7 M) and rapid pacing produces a single TA complex (upward arrow points to the TA), and downward arrow indicates DAD. B: Isoproterenol and Tempo with the same pacing protocol; no TA was observed although DAD is still present. C: With 15-minute washout, 3 TAs were again induced. Heart Rhythm 2009 6, DOI: (10.1016/j.hrthm.2009.09.027) Copyright © 2009 Terms and Conditions

New figure (above): Recordings in standard electrolyte solution (in vitro) without isoproterenol from an excised ischemic site (Purkinje cell) with horizontal zero lines and voltage and time calibrations (different for A and B vs C and D). A: Sustained triggered activity (TA) is induced with rapid pacing (last stimulated indicated by the upgoing arrow). B: TA of 10 complexes produced by pacing despite superfusion with TEMPO 10−4 M. Note the last complex of TA is preceded by a delayed afterdepolarization (DAD) and after the TA a small DAD (downgoing arrow) occurs without achieving threshold. Not shown are similar data with TEMPO 10−3 M. C: No TA induced with TEMPO 10−2 M but spontaneous phase 4 depolarization achieves threshold. D: TA (one) and DAD again observed after 20 minutes wash out of TEMPO. Heart Rhythm 2009 6, DOI: (10.1016/j.hrthm.2009.09.027) Copyright © 2009 Terms and Conditions