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A presentation to: Meeting name Date Corticosteroid implants for chronic non-infectious uveitis Christopher J Brady, Andrea C Villanti, H Andrew Law, Ehsan Rahminy, Rahul Reddy, Pamela C Sieving, Sunir J Garg, Johnny Tang Issue 2, 2016 A presentation to: Meeting name Date

Table of Contents 01 Background 02 Types of studies 03 Key results 04 Tables (Risk of Bias/Forest Plots) 05 Conclusions 06 Acknowledgements

01: Background Uveitis, which many types of intraocular inflammatory diseases, is treated with corticosteroids Steroid implants are gaining ground as an alternative treatment Objective: To determine the efficacy and safety of steroid implants in people with chronic non-infectious posterior uveitis, intermediate uveitis, and panuveitis

02: Types of studies Participants Two randomized controlled trials, 619 eyes of 401 participants Interventions Fluocinolone acetonide (FA) implants VERSUS Standard-of-care therapy

03: Key results “a FA implant probably prevents recurrence of uveitis compared with standard-of-care therapy” RR 0.29, 95% CI 0.14 to 0.59; 132 eyes “increased risks of needing cataract surgery… in the implant group compared with standard-of-care therapy” RR 2.98, 95% CI 2.33 to 3.79, 371 eyes “increased risks of needing… surgery to lower intraocular pressure in the implant group compared with standard-of-care therapy” RR 7.48, 95% CI 3.94 to 14.19, 599 eyes

04: Tables

04: Tables Cataract surgery through 24 months

04: Tables IOP-lowering surgery performed through 24 months

05: Conclusions “After considering both benefits and harms reported from two studies in which corticosteroids implants were compared with standard-of-care therapy, we are unable to conclude that the implants are superior to traditional systemic therapy for the treatment of non-infectious uveitis.”

06: Acknowledgements Cochrane Eyes and Vision US Satellite, funded by the National Eye Institute, National Institutes of Health Cochrane Eyes and Vision Editorial Base, funded by the UK National Health Service Research and Development Programme Christopher J Brady, Andrea C Villanti, H Andrew Law, Ehsan Rahminy, Rahul Reddy, Pamela C Sieving, Sunir J Garg, Johnny Tang Review citation Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J. Corticosteroid implants for chronic non-infectious uveitis. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD010469. DOI: 10.1002/14651858.CD010469.pub2.