RNAi Delivers Insights into Liver Cancer

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RNAi Delivers Insights into Liver Cancer René Bernards Cell Volume 135, Issue 5, Pages 793-795 (November 2008) DOI: 10.1016/j.cell.2008.11.001 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Identifying Liver Cancer Tumor Suppressor Genes High-resolution array comparative genome hybridization (CGH) of a panel of hepatocellular carcinomas allowed the identification of a number of genes in areas of recurrent copy number loss. Knockdown vectors delivering short hairpin RNAs (shRNAs) were generated against the murine orthologs of these candidate tumor suppressor genes. These vectors were then introduced into immortal but nontumorigenic murine hepatocytes and injected into mice. shRNAs capable of producing a tumorigenic phenotype are likely tumor suppressor genes in hepatocellular carcinoma. Cell 2008 135, 793-795DOI: (10.1016/j.cell.2008.11.001) Copyright © 2008 Elsevier Inc. Terms and Conditions