Figure 6. Representative micrographs showing macrophages and nitrotyrosine in atherosclerotic plaques in aortic root cross-sections from apo-E −/− mice.

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Figure 6. Representative micrographs showing macrophages and nitrotyrosine in atherosclerotic plaques in aortic root cross-sections from apo-E −/− mice with CRF. p, plaque; lu, aortic lumen. Figure 6. Representative micrographs showing macrophages and nitrotyrosine in atherosclerotic plaques in aortic root cross-sections from apo-E −/− mice with CRF. p, plaque; lu, aortic lumen. (A) Macrophage staining with a CD11b monoclonal antibody shows accumulation of macrophages in the plaque of a uremic apo-E −/− mouse 12 wk after induction of renal failure. Insert: negative control (no specific primary antibody). (B) Staining for nitrotyrosine with an anti-nitrotyrosine antibody in the plaque of a uremic apo-E −/− mouse. Strong staining for nitrotyrosine is predominantly localized within the core of the plaque. Insert: staining for nitrotyrosine in arterial wall with normal histology from a uremic apo-E −/− mouse. Magnification, ×200. Susanne Bro et al. JASN 2003;14:2466-2474 ©2003 by American Society of Nephrology