Smoking and Adverse Outcomes in Patients With CKD: The Study of Heart and Renal Protection (SHARP)  Natalie Staplin, PhD, Richard Haynes, DM, William G. Herrington, MD, Christina Reith, FRCP, Alan Cass, FRACP, Bengt Fellström, MD, Lixin Jiang, MD, Bertram L. Kasiske, MD, Vera Krane, MD, Adeera Levin, FRCPC, Robert Walker, FRACP, Christoph Wanner, MD, David C. Wheeler, FRCP, Martin J. Landray, PhD, Colin Baigent, FRCP, Jonathan Emberson, PhD Colin Baigent, Martin J. Landray, Christina Reith, Jonathan Emberson, David C. Wheeler, Charles Tomson, Christoph Wanner, Vera Krane, Alan Cass, Jonathan Craig, Bruce Neal, Lixin Jiang, Lai Seong Hooi, Adeera Levin, Lawrence Agodoa, Mike Gaziano, Bertram L. Kasiske, Robert Walker, Ziad A. Massy, Bo Feldt-Rasmussen, Udom Krairittichai, Vuddidhej Ophascharoensuk, Bengt Fellström, Hallvard Holdaas, Vladimir Tesar, Andrzej Wiecek, Diederick Grobbee, Dick de Zeeuw, Carola Grönhagen-Riska, Tanaji Dasgupta, David Lewis, William G. Herrington, Marion Mafham, William Majoni, Karl Wallendszus, Richard Grimm, Terje Pedersen, Jonathan Tobert, Jane Armitage, Alex Baxter, Christopher Bray, Yiping Chen, Zhengming Chen, Michael Hill, Carol Knott, Sarah Parish, David Simpson, Peter Sleight, Alan Young, Rory Collins Natalie Staplin, PhD, Richard Haynes, DM, William G. Herrington, MD, Christina Reith, FRCP, Alan Cass, FRACP, Bengt Fellström, MD, Lixin Jiang, MD, Bertram L. Kasiske, MD, Vera Krane, MD, Adeera Levin, FRCPC, Robert Walker, FRACP, Christoph Wanner, MD, David C. Wheeler, FRCP, Martin J. Landray, PhD, Colin Baigent, FRCP, Jonathan Emberson, PhD Colin Baigent, Martin J. Landray, Christina Reith, Jonathan Emberson, David C. Wheeler, Charles Tomson, Christoph Wanner, Vera Krane, Alan Cass, Jonathan Craig, Bruce Neal, Lixin Jiang, Lai Seong Hooi, Adeera Levin, Lawrence Agodoa, Mike Gaziano, Bertram L. Kasiske, Robert Walker, Ziad A. Massy, Bo Feldt-Rasmussen, Udom Krairittichai, Vuddidhej Ophascharoensuk, Bengt Fellström, Hallvard Holdaas, Vladimir Tesar, Andrzej Wiecek, Diederick Grobbee, Dick de Zeeuw, Carola Grönhagen-Riska, Tanaji Dasgupta, David Lewis, William G. Herrington, Marion Mafham, William Majoni, Karl Wallendszus, Richard Grimm, Terje Pedersen, Jonathan Tobert, Jane Armitage, Alex Baxter, Christopher Bray, Yiping Chen, Zhengming Chen, Michael Hill, Carol Knott, Sarah Parish, David Simpson, Peter Sleight, Alan Young, Rory Collins  American Journal of Kidney Diseases  Volume 68, Issue 3, Pages 371-380 (September 2016) DOI: 10.1053/j.ajkd.2016.02.052 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Relevance of baseline smoking status to vascular outcomes, (A) overall and (B) separately by history of cardiovascular disease (CVD) or diabetes. Relative risks are adjusted for age, sex, ethnicity, country, education, and for (A) only, prior disease (prior CVD and diabetes) and are quoted above the squares. Numbers of events in each group are quoted below the squares. Abbreviation: CI, confidence interval. American Journal of Kidney Diseases 2016 68, 371-380DOI: (10.1053/j.ajkd.2016.02.052) Copyright © 2016 The Authors Terms and Conditions

Figure 2 Relevance of baseline smoking status to (A) cancer incidence and (B) site-specific cancer. All relative risks (RRs) and annual event rates are adjusted for age, sex, ethnicity, country, education, and prior disease (prior cardiovascular and diabetes). In (A), RRs are quoted above the squares with numbers of events quoted below the squares. Abbreviations: CI, confidence interval; py, per year. American Journal of Kidney Diseases 2016 68, 371-380DOI: (10.1053/j.ajkd.2016.02.052) Copyright © 2016 The Authors Terms and Conditions

Figure 3 Relevance of baseline smoking status to renal progression among 6,245 patients not on dialysis therapy at randomization. Relative risks are adjusted for age, sex, ethnicity, country, education, and prior disease (prior cardiovascular and diabetes) and are quoted above the squares with the number of events quoted below the squares. Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease. American Journal of Kidney Diseases 2016 68, 371-380DOI: (10.1053/j.ajkd.2016.02.052) Copyright © 2016 The Authors Terms and Conditions

Figure 4 Relevance of baseline smoking status to cause-specific mortality, (A) overall and (B) separately by history of cardiovascular disease (CVD) or diabetes. Relative risks are adjusted for age, sex, ethnicity, country, education, and for (A) only, prior disease (prior CVD and diabetes) and are quoted above the squares. Numbers of events in each group are quoted below the squares. Abbreviation: CI, confidence interval. American Journal of Kidney Diseases 2016 68, 371-380DOI: (10.1053/j.ajkd.2016.02.052) Copyright © 2016 The Authors Terms and Conditions