An Elegan(t) Screen for Drug-Microbe Interactions

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An Elegan(t) Screen for Drug-Microbe Interactions Alison Vrbanac, Justine W. Debelius, Lingjing Jiang, James T. Morton, Pieter Dorrestein, Rob Knight  Cell Host & Microbe  Volume 21, Issue 5, Pages 555-556 (May 2017) DOI: 10.1016/j.chom.2017.04.014 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 High-Throughput Screening of Bacterial Mutants Uncovers Key Genes in Microbial-Host Fluoropyrimidine Metabolism An overview of the pathways involved in 5-FU efficacy in a small slice of a high-throughput screen. Loss of upp inhibits RNA damage through ribonucleotide metabolism, resulting in increased C. elegans resistance to 5-FU. Cell Host & Microbe 2017 21, 555-556DOI: (10.1016/j.chom.2017.04.014) Copyright © 2017 Elsevier Inc. Terms and Conditions

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