EGFR and KRAS Mutations in Triple-Mutated Lung Cancer

Slides:



Advertisements
Similar presentations
Lung Adenocarcinoma with Ipsilateral Breast Metastasis: A Simple Coincidence? Hsu-Ching Huang, MD, Jen-Fan Hang, MD, Mei-Han Wu, MD, Teh-Ying Chou, MD,
Advertisements

The Accuracy of Frozen Section Diagnosis of Pulmonary Nodules: Evaluation of Inflation Method during Intraoperative Pathology Consultation with Cryosection.
A Case of a Patient with Idiopathic Pulmonary Fibrosis with Lung Squamous Cell Carcinoma Treated with Nivolumab  Monica Khunger, MD  Journal of Thoracic.
Successful Osimertinib Rechallenge in a Patient with T790M-Mutant Non–Small Cell Lung Cancer after Osimertinib-Induced Interstitial Lung Disease  Eisaku.
Next Generation Sequencing Uncovers Potential Genetic Driver Mutations of Malignant Pulmonary Granular Cell Tumor  Song Xu, Qingchun Zhao, Sen Wei, Yi.
Hironori Yoshida, MD, Young Hak Kim, MD  Journal of Thoracic Oncology 
Chia-Lin Hsu, MD, Kuan-Yu Chen, MD, PhD  Journal of Thoracic Oncology 
Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib  Nobukazu Agatsuma, MD  Journal of.
Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib  Nobukazu Agatsuma, MD  Journal of.
Rapid Acquisition of T790M Mutation after Treatment with Afatinib in an NSCLC Patient Harboring EGFR Exon 20 S768I Mutation  Alessandro Russo, MD, Tindara.
Durable Response to Tyrosine Kinase Inhibitor Therapy in a Lung Cancer Patient Harboring Epidermal Growth Factor Receptor Tandem Kinase Domain Duplication 
Erlotinib Response in an NSCLC Patient with a Novel Compound G719D+L861R Mutation in EGFR  Eamon M. Berge, MD, Dara L. Aisner, MD, PhD, Robert C. Doebele,
Nivolumab Enhances the Inflammation of the Irradiation Field in Advanced Non–Small Cell Lung Cancer  Hiromi Furuta, MD, PhD, Tatsuya Yoshida, MD, PhD,
MET-Mutated NSCLC with Major Response to Crizotinib
A Case of a Patient with Idiopathic Pulmonary Fibrosis with Lung Squamous Cell Carcinoma Treated with Nivolumab  Monica Khunger, MD  Journal of Thoracic.
Evaluation of Kras Gene Mutation and Copy Number in Thymic Carcinomas and Thymomas  Hidefumi Sasaki, MD, PhD, Motoki Yano, MD, PhD, Yoshitaka Fujii, MD,
Zeynep Eroglu, MD, Jae Kim, MD, Sharon Wilczynski, MD, PhD, Warren A
KRAS Mutation Analysis Helps to Differentiate Between Pulmonary Metastasis from Colon Adenocarcinoma In Situ and Primary Lung Adenocarcinoma  Taylor M.
Electronic Updates for JTO Readers
IA05.01 Lung Cancer Cases Journal of Thoracic Oncology
Complete Response Achieved 1 Year after a Single Administration of Nivolumab in a Patient with Lung Adenocarcinoma with Negative Expression of PD-L1 
An Unusual Presentation of Malignant Pleural Mesothelioma
Hironori Yoshida, MD, Young Hak Kim, MD  Journal of Thoracic Oncology 
Coexistence of the BRAF Mutation and EGFR Exon 20 Insertion in a Patient with Lung Adenocarcinoma  Lih-Chyun Chang, MD, Kuan-Yu Chen, MD, PhD, Jin-Yuan.
Atypical Pleuropulmonary Tuberculosis Mimicking a Malignant Disease
Frank Detterbeck, MD  Journal of Thoracic Oncology 
Successful Treatment with Erlotinib after Gefitinib-Induced Severe Interstitial Lung Disease  Masayuki Takeda, MD, PhD, Isamu Okamoto, MD, PhD, Chihiro.
A Severe Photosensitivity Dermatitis Caused by Crizotinib
A Case of Invasive Mucinous Pulmonary Adenocarcinoma with a CD74-NRG1 Fusion Protein Targeted with Afatinib  Parneet K. Cheema, MD, MBiotech, FRCPC  Journal.
Patients’ Knowledge, Beliefs, and Distress Associated with Detection and Evaluation of Incidental Pulmonary Nodules for Cancer: Results from a Multicenter.
Effective Treatment with Icotinib in Primary Adenoid Cystic Carcinoma of the Lung with Liver Metastasis  Zhengbo Song, MD, Wei Wu, MD, Yiping Zhang, MD 
Association between Congenital Lung Malformations and Lung Tumors in Children and Adults: A Systematic Review  Arianna Casagrande, MD, Federica Pederiva,
Geographic Variation in EGFR Mutation Frequency in Lung Adenocarcinoma May Be Explained by Interethnic Genetic Variation  Lars Soraas, MSc, Justin Stebbing,
Vamsidhar Velcheti, MD, Manmeet Ahluwalia, MD 
Strategies to Improve Outcomes of Patients with EGFR-Mutant Non–Small Cell Lung Cancer: Review of the Literature  Caicun Zhou, MD, PhD, Luan Di Yao, MD 
Coexistence of Tyrosine Kinase Inhibitor-Sensitizing and Resistant EGFR Mutations in an Untreated Lung Adenocarcinoma Patient and Response to Erlotinib 
A Different Method in Diagnosis of Multiple Primary Lung Cancer
Nivolumab-Induced Acute Diabetes Mellitus and Hypophysitis in a Patient with Advanced Pulmonary Pleomorphic Carcinoma with a Prolonged Tumor Response 
Four-Year Complete Remission in a Patient with Metastatic Epidermal Growth Factor Receptor–Mutated Lung Cancer Treated with Two Cycles of Erlotinib  Brendan.
Non–Small-Cell Lung Cancer with HER2 Exon 20 Mutation: Regression with Dual HER2 Inhibition and Anti-VEGF Combination Treatment  Gerald S. Falchook, MD,
Elizabeth Cathcart-Rake, MD, Ariel Lopez-Chavez, MD, MS 
Steve R. Siegal, MD, John G. Hunter, MD, James P. Dolan, MD, MCR 
Vamsidhar Velcheti, MD  Journal of Thoracic Oncology 
The Role of Surgery in the Management of Primary Thymic Mucosa-associated Lymphoid Tissue (MALT) Lymphoma  Kimihiro Shimizu, MD, PhD, Izumi Takeyoshi,
Jennifer L. Dallas, MD, Michael A. Jantz, MD, Judith L
Combination Treatment Using an EGFR Tyrosine Kinase Inhibitor plus Platinum-Based Chemotherapy for a Patient with Transformed Small Cell Carcinoma and.
An Unmet Need in the WHO 2015 Biopsy Classification: Poorly Differentiated NSCCs with Positive Neuroendocrine Markers  Jules L. Derks, MD  Journal of.
Osimertinib for Epidermal Growth Factor Receptor Mutation–Positive Lung Adenocarcinoma That Transformed to T790M-Positive Squamous Cell Carcinoma  Naoyuki.
EGFR delE709_T710insD: A Rare but Potentially EGFR Inhibitor Responsive Mutation in Non–Small-Cell Lung Cancer  Allison Ackerman, MD, Michael A. Goldstein,
S768I Mutation in EGFR in Patients with Lung Cancer
CT Features of Epidermal Growth Factor Receptor–Mutated Adenocarcinoma of the Lung: Comparison with Nonmutated Adenocarcinoma  Mizue Hasegawa, MD, PhD,
Nivolumab-Induced Granulomatous Inflammation of the Pleura
PTEN and PIK3CA Expression Is Associated with Prolonged Survival after Gefitinib Treatment in EGFR-Mutated Lung Cancer Patients  Hideki Endoh, MD, PhD,
Multiple Pulmonary Nodules in an Elderly Woman
Compound Uncommon EGFR Mutations in a Patient with Advanced NSCLC and Durable Response to Sequential EGFR Targeted Therapies  Mary Linton B Peters, MD,
T4 or MI? Journal of Thoracic Oncology Volume 6, Issue 3, (March 2011)
Driven by Mutations: The Predictive Value of Mutation Subtype in EGFR-Mutated Non– Small Cell Lung Cancer  Emily Castellanos, MD, Emily Feld, MD, Leora.
M. Kusumoto  Journal of Thoracic Oncology 
Two Generations of Light/Never-Smokers With Advanced Adenocarcinoma of the Lung with Durable Responses to Erlotinib  Nathan A. Pennell, MD, PhD, Lihong.
Antiangiogenesis Induced Tumor Cavitation in Lung Cancer
Recurrent Primary Synovial Sarcoma of the Chest Wall
Impressive Response to Tyrosine Kinase Inhibitors in a Patient with Respiratory Failure for EGFR-Mutated Metastatic Lung Cancer  Elena Bolzacchini, MD,
Tetsuzo Tagawa, MD, Miyuki Takasu, MD, Teruyoshi Ishida, MD 
Acquired Mechanism of Crizotinib Resistance in NSCLC with MET Exon 14 Skipping  Wei Jin, MD, Benjie Shan, MD, Hu Liu, PhD, Shoubing Zhou, PhD, Wenjuan.
Tumor Lysis Syndrome in Limited-Stage Small-Cell Lung Cancer
Two Rare Exon 21 EGFR Mutations in Patients Treated with Gefitinib
Lack of FDG Uptake in Small Cell Carcinoma Associated with ANNA-1 Positive Paraneoplastic Autonomic Neuropathy  Matthew S. Block, MD, PhD, Robert Vassallo,
Robert Comis, MD, The Passing of a “Lung Man”
Ana Luque, MD, Edurne Arriola, MD, PhD  Journal of Thoracic Oncology 
Reply to “Influence of Body Mass Index on Overall Survival Following Surgical Resection of Non–Small Cell Lung Cancer: Methodological Issues”  Boris Sepesi,
Presentation transcript:

EGFR and KRAS Mutations in Triple-Mutated Lung Cancer Ryohei Yoshida, MD, Takaaki Sasaki, MD, PhD, Yoshinobu Ohsaki, MD, PhD  Journal of Thoracic Oncology  Volume 12, Issue 7, Pages e92-e93 (July 2017) DOI: 10.1016/j.jtho.2017.02.022 Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Computed tomography (CT) imaging of the three bilateral pulmonary nodules along with pathologic findings and driver and other mutations. COSMIC, Catalogue of Somatic Mutations in Cancer; ID, identifier; Lt. left; COSM, Catalogue of Somatic Mutations in Cancer; NF1, neurofibromin 1 gene; EP400, 1A binding protein p400; SYNE1, spectrin repeat containing nuclear envelope protein 1 gene; Rt., right. Journal of Thoracic Oncology 2017 12, e92-e93DOI: (10.1016/j.jtho.2017.02.022) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions