Lab 5- ALS, Trigeminal System

ALS

Note Cell body locations: ALS AN OVERVIEW OF THE ANTEROLATERAL SYSTEM FOR PAIN AND TEMPERATURE SENSATION Note Cell body locations: Primary sensory afferent cell bodies DRG all levels of the spinal cord Fast fibers – Ad fibers intense sharp pain Slow Fibers – C fibers dull throbbing, burning pain Primary Central Processes enter via lateral aspect of dorsal roots Ventral white commisure

Haines 5-1 Lamina 1+5 = projection neurons pain and temp. Lissauers tract in dorsal horn Lamina 2+3 = Substantia gelatinosa -receives afferents ALS Ventral White Commisure Sacral Level

Haines 5-2 Lissauers tract in dorsal horn Lamina 1+5 = projection neurons pain and temp. Lamina 2+3 = Substantia gelatinosa -receives afferents ALS Ventral White Commisure Lumbar Level

Haines 5-3 Lamina 5 = projection neurons pain and temp. Lissauers tract in dorsal horn Lamina 1+2 ALS Ventral White Commisure Thoracic Level

Haines 5-4 Lamina 5 = projection neurons pain and temp. Lissauers tract in dorsal horn Lamina 2 Substantia gelatinosa -receives afferents ALS Ventral White Commisure C7 Level

Haines 5-5 Lamina 5 = projection neurons pain and temp. Lissauers tract in dorsal horn Substantia gelatinosa -receives afferents ALS Ventral White Commisure C1 Level

Haines 5-9 Tegmentum = Reticular Formation + Periventricular Zone Keep in Mind that the reticular formation is a poorly defined area. ALS Fast Fibers Caudal Medulla Level

Haines 5-11 ALS Midrostral Medulla Level Reticular Formation – receives slow ALS fibers that take Multisynaptic course Haines 5-11 ALS Fast fiber Midrostral Medulla Level

Haines 5-12 ALS Rostral Medulla Level Reticular Formation – receives slow ALS fibers that take Multisynaptic course ALS Fast fiber Rostral Medulla Level Raphe Nucleus – Decending Pain Block (Serotonin or NorEp)

Haines 5-17 ALS Rostral Medulla Level Reticular Formation – receives slow ALS fibers that take Multisynaptic course ALS Fast fiber Rostral Medulla Level Raphe Nucleus – Decending Pain Block (Serotonin or NorEp)

Haines 5-19 ALS Rostral Pons Level Reticular Formation – receives slow ALS fibers that take Multisynaptic course Haines 5-19 ALS Fast fiber Rostral Pons Level Raphe Nucleus – Decending Pain Block (Serotonin or NorEp)

Haines 5-20 ALS Rostral Pons Level Reticular Formation – receives slow ALS fibers that take Multisynaptic course ALS Fast fibers Medial Lemniscus Rostral Pons Level

Haines 5-22 Reticular Formation – receives slow ALS fibers that take Multisynaptic course Periaqueductal Gray – receives fibers from ALS, and sends decending fibers to the Raphe Nucleus ALS Fast fibers Pons/midbrain jctn Level

Periaqueductal Gray – receives fibers from ALS, and sends decending fibers to the Raphe Nucleus Haines 5-25 Reticular Formation – receives slow ALS fibers that take Multisynaptic course ALS Fast Fibers Rostral Midbrain Level

Haines 5-30 Contains fibers from both: ALS and Medial Lemniscus Thalmus

Haines 5-31 Slow Tract Receives pain and temp fibers from reticular formation and sends axons to different areas of the cortex.

Black Board 28

Black Board 29

Black Board 30

Black Board 31

Black Board 33 Posterior limb of internal capsule

Trigeminal System

Tigeminal System (CN5) (1) (2) (3) VTTT Trigeminal nuclear Complex unconscious proprioceptors (2) Note: Fibers cross the midline Trigeminal nuclear Complex (3)

Haines 5-8 Spinaltrigeminal Nucleus Spinaltrigeminal tract – ipsilateral pain and temp from face and teeth Caudal Medulla

Haines 5-9 Spinaltrigeminal Nucleus – sends axons that cross at accend to VPM Spinaltrigeminal tract – ipsilateral pain and temp from face and teeth Caudal Medulla Level

Axons cross and ascend in to VTTT at the caudal pons and continue to the VPM Haines 5-11 Spinaltrigeminal Nucleus Spinaltrigeminal tract – ipsilateral pain and temp from face and teeth Midrostral Medulla Level

Haines 5-12 Spinaltrigeminal Nucleus Spinaltrigeminal tract Rostral Medulla Level

Haines 5-17 Spinaltrigeminal Nucleus Spinaltrigeminal tract Rostral Medulla Level

Haines 5-19 Main Motor Nucleus Trigeminal Roots Main Sensory Nucleus Supplies muscles of mastication Trigeminal Roots Main Sensory Nucleus Discriminative touch Receives fibes from trigem ganglion Sends axons across midline to VTTT Mixed VTTT Contralateral spinotrgeminal tract (Ipsilateral) Rostral Pons Level

Haines 5-25 VTTT Contralateral Rostral Midbrain Level

Haines 5-30 VPM = sensory relay nucleus for general face sensation and for taste Posteror Limb of Internal Capsule Thalmus

Haines 2-11