Figure 3. Severity of aortic atherosclerosis in apo-E −/− mice with CRF. Aortic plaque area fraction (A), aortic cholesterol content (B), and aortic root.

Slides:

Advertisements

Similar presentations

Atherosclerotic lesion area within the aortic sinus of apoE - / - and apoE - / - - hCRP + mice Gideon M. Hirschfield et al. PNAS 2005;102:8309– 8314.

Advertisements

Genes Within the MHC Region Have a Dramatic Influence on Radiation-Enhanced Atherosclerosis in MiceClinical Perspective by Weibin Shi, Zhimin Zhang, Mei-Hua.

Assessment of Unstable Atherosclerosis in Mice

Relationship between urinary TNF-α and RANTES excretion

Key amino acid positions identified by association analysis are highlighted in three-dimensional ribbon models for the HLA-DR, HLA-DQ, HLA-A and HLA-DP.

Differential expression of select miRNAs was validated in a second cohort of patients. Differential expression of select miRNAs was validated in a second.

Podocyte-specific PPAR-γ–deficient mice show increased glomerular TRPC6 expression. Podocyte-specific PPAR-γ–deficient mice show increased glomerular TRPC6.

Inhibition of ILK by QLT-0267 abrogates PAI-1 and MMP-2 induction by TGF-β1 in tubular epithelial cells. Inhibition of ILK by QLT-0267 abrogates PAI-1.

Antibody–mediated C5 inhibition in hepatocyte-Cfh−/− mice during accelerated serum NTN. (A) Hematuria, (B) serum urea, (C) red cell fragments, (D) glomerular.

Two independent amino acid positions were identified after stepwise association analysis for amino acids in HLA-DRβ1, HLA-DQα1 and HLA-DQβ1 in the combined.

Figure 1. Relationship between (A) total antioxidative activity (TAA) and endothelium-dependent vasodilation (EDV) (r = 0.41, P = 0.016), (B) lag phase.

Missense mutations in TNXB as a cause of VUR

Figure 6. Representative micrographs showing macrophages and nitrotyrosine in atherosclerotic plaques in aortic root cross-sections from apo-E −/− mice.

Figure 2. Plasma lipoprotein cholesterol in apo-E −/− mice with CRF

Pedigrees of the families of patients 1 and 2 show that the clinical phenotype co-segregates with compound heterozygous CLDN10 variants. Pedigrees of the.

Figure 1. Plasma urea concentrations in apolipoprotein E–deficient (apo-E −/−) mice with chronic renal failure (CRF). Figure 1. Plasma urea concentrations.

Schematic representations of DGKE protein and mRNA illustrating the relative positions of all pathogenic mutations reported to date. Schematic representations.

Volume 67, Issue 6, Pages (June 2005)

Cytokine and chemokine expression of flucloxacillin-specific T cell clones (TCC) of patient P1. Cytokine and chemokine expression of flucloxacillin-specific.

Studies reporting the incident rate for all types of infections per 1000 patient days. Studies reporting the incident rate for all types of infections.

Figure 10. Recovery of the acetyl-CoA and ATP levels by glucose administration. Figure 10. Recovery of the acetyl-CoA and ATP levels by glucose administration.

Several microRNAs are differentially expressed in the glomeruli between different types of kidney disease. Several microRNAs are differentially expressed.

Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10 by Alma Zernecke, Elisa A. Liehn,

Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis by Janka Kisucka, Anil.

INT-767 treatment prevents the increase in renal inflammation and oxidative stress in diabetic DBA/2J mice. INT-767 treatment prevents the increase in.

INT-767 treatment prevents the increase in renal HIF and Glut1 expression and ER stress in diabetic DBA/2J mice. INT-767 treatment prevents the increase.

INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice.

Renal microvascular injury 6 months after induction of JG cell-specific Gsα knockout. Renal microvascular injury 6 months after induction of JG cell-specific.

The proportion of DCD donor kidneys discarded was correlated with the proportion of NBD donor kidneys discarded within DSAs (Pearson correlation coefficient.

The incidence of all cause graft failure, and death with a functioning graft was higher in patients who received a DCD donor transplant with total donor.

VEGF signals via a paracrine loop to VEGFR-2 in the glomerulus.

Model of human CLC-Kb transporter topology and positions of amino acid exchanges due to mutations in the CLCNKB gene as identified in Bartter syndrome.

Mitochondria-associated membranes in proximal tubules after ischemia.

Hajer GR et al. Atherosclerosis 2009;202:216-24

Volume 89, Issue 5, Pages (May 2016)

LV.IDS and LV.IDS.ApoEII improve brain‐specific IDS activity and express supra‐physiological levels of active IDS in peripheral organs LV.IDS and LV.IDS.ApoEII.

The increased cytosolic and nuclear β-catenin in the tubular epithelial cells of 7-d obstructed kidneys is suppressed by recombinant sFRP4. The increased.

Trend of overall improvement in CKD risk categories after bariatric surgery using year 1 post-surgery as baseline. Trend of overall improvement in CKD.

Target engagement of the systemic Stat3 inhibitor in APP/PS1 mice

Comparison of CMR and echocardiography in aortic regurgitation.

(A through C) Mean eGFR during follow-up according to treatment assignment in patients with normoalbuminuria (A), microalbuminuria (B), and macroalbuminuria.

Figure 4. p38α mitogen-activated protein kinase (MAPK) blockade reduces interstitial volume in obstructed kidneys but does not reduce the number of infiltrating.

Urine ammonia is highly correlated with plasma K

DCT-CA-SPAK mice exhibit characteristics of Type 4 RTA, i. e

Correcting hyperkalemia in DCT-CA-SPAK mice with a low K diet corrects differences in ammonia excretion and inducing hyperkalemia in WT mice, with the.

Rena Watanabe et al. BTS 2016;1:

Thirty-day survival curves for the rapid versus slow correction rate groups are not significantly different. Thirty-day survival curves for the rapid versus.

Emre Seli, M. D. , Ozlem Guzeloglu-Kayisli, Ph. D. , Umit A

ILK knockdown decreases mTOR signaling in PKD kidneys.

ILK knockdown increases the survival of PKD mice.

LXs reverse established DKD. (A) Study design overview.

Figure 5. Tissue uptake of circulating 125I-β2-m.

Relative risk of a major coronary heart disease event (myocardial infarction incidence, fatal coronary heart disease, or coronary revascularization) for.

The insulin tolerance test at week 18.

Figure 1. Genomic organization of the murine Pcln1 gene.

Vitamin K2 supplementation reduces dp-ucMGP but not dp-cMGP levels in dialysis patients. Vitamin K2 supplementation reduces dp-ucMGP but not dp-cMGP levels.

Box plots showing the relative difference in distribution of mtDNA copy number per cell between patients with ESRD and healthy control subjects frequency.

Figure 3. Effect of spironolactone or albumin conjugation on the vasoconstrictor action of aldosterone in afferent arterioles (left) and efferent arterioles.

Fig. 2. CD treatment facilitates regression of murine atherosclerosis.

Plaque area remained increased in the previously hyperglycemic mice.

Analysis of renal transcriptome responses identifies LX-regulated transcriptional networks. Analysis of renal transcriptome responses identifies LX-regulated.

Ca2+ infusion rates during all three protocol versions.

Matthias Nahrendorf et al. JIMG 2009;2:

Class 1 phosphatidylinositol 3-kinase (PI3K) p85 subunit dominant negative adenovirus regulates Pax2 and GAPDH abundance in NRK-52E cells. Class 1 phosphatidylinositol.

TDF-induced epithelial cell dysfunction is due to mitochondrial damage

The dopamine (DA) response to cocaine infusion in the NAc in constitutive p11 KO mice is restored by nicotinic or muscarinic receptor stimulation in the.

Distribution of percent consistent facility aspirin use.

Separation in achieved BP levels between the two intervention groups in the SPRINT participants with CKD. The broken line and open circles denote the intensive.

Distribution of SDS for serum creatinine, serum BUN, SBP, and DBP per quintiles of KS. Quintiles are expressed in SDS (see Figure 1B): 1st quintile,

The development of proteinuria and renal insufficiency after unilateral nephrectomy according to body mass index at the time of surgery. The development.

Presentation transcript:

Figure 3. Severity of aortic atherosclerosis in apo-E −/− mice with CRF. Aortic plaque area fraction (A), aortic cholesterol content (B), and aortic root plaque area (C) in CRF mice (▪, n = 28), UNX mice (▨, n = 24), and no-surgery mice (□, n = 23). Figure 3. Severity of aortic atherosclerosis in apo-E −/− mice with CRF. Aortic plaque area fraction (A), aortic cholesterol content (B), and aortic root plaque area (C) in CRF mice (▪, n = 28), UNX mice (▨, n = 24), and no-surgery mice (□, n = 23). Values are mean ± SEM. P values for two-group comparisons indicated by brackets are included in the figures. Susanne Bro et al. JASN 2003;14:2466-2474 ©2003 by American Society of Nephrology