Tooth Be Told, Genetics Influences Oral Microbiome Emily R. Davenport  Cell Host & Microbe  Volume 22, Issue 3, Pages 251-253 (September 2017) DOI: 10.1016/j.chom.2017.08.018 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Candidate Host Secreted Molecules that May Influence Heritability of the Oral Microbiome Saliva and epithelial tissues in the mouth contain a number of molecules with known genetic variation. Proline-rich proteins (PRPs) make up a major component of saliva and influence bacterial attachment to tooth surfaces. Mucins act as tethering and energy sources for particular microbes. Immune molecules and other small molecules (histatins, defensins, etc.) regulate bacterial composition in the mouth and prevent pathogen colonization. Taste receptors contribute to dietary preferences and certain enzymes break down food, such as amylase. Both of these classes of molecules create different nutritional content available for oral bacteria. Finally, salivary flow rate determines the concentrations of these molecules and electrolytes. Cell Host & Microbe 2017 22, 251-253DOI: (10.1016/j.chom.2017.08.018) Copyright © 2017 Elsevier Inc. Terms and Conditions