Diana G. Redwood, PhD, Elvin D. Asay, MS, Ian D. Blake, MS, Pamela E

Slides:

Advertisements

Similar presentations

My Treatment Approach to Hairy Cell Leukemia Rahul R. Naik, MD, Alan Saven, MD Mayo Clinic Proceedings Volume 87, Issue 1, Pages (January 2012) DOI:

Advertisements

Celebrating the Sesquicentennial of Mayo Clinic: 150 Years of Advances in Medical Practice, Education, Research, and Professionalism William L. Lanier,

Untitled (Sailboats) by Leo Sewell

Flowers in Vase and Table Setting by William Schulman

Pleomorphic Adenoma in the Parotid Gland

Ductal Carcinoma in Situ of the Breast

Ultraviolet Purpura in IgA Vasculitis

Toward a Strategy of Patient-Centered Access to Primary Care

J. Eric Ahlskog, PhD, MD Mayo Clinic Proceedings

Robert M. Jacobson, MD, George J. Isham, MD, MS, Lila J

Approach to the Patient With Hematochezia

Fresh vs Frozen Samples and Ambient Temperature Have Little Effect on Detection of Colorectal Cancer or Adenomas by a Fecal Immunochemical Test in a Colorectal.

Increasing Cardiac Rehabilitation Participation From 20% to 70%: A Road Map From the Million Hearts Cardiac Rehabilitation Collaborative Philip A. Ades,

Toward a Strategy of Patient-Centered Access to Primary Care

Mucinous Neoplasm of the Appendix and Pseudomyxoma Peritonei

Review of Childhood Obesity

Mythological Botanical No. 1 and No. 2 by Trudy Kraft

Direct Comparison of Diagnostic Performance of 9 Quantitative Fecal Immunochemical Tests for Colorectal Cancer Screening Anton Gies, Katarina Cuk, Petra.

Vulvovaginal Issues in Mature Women

Understanding Palliative Care and Hospice

Long Survival and Severe Toxicity Under 5-Fluorouracil–Based Therapy in a Patient With Colorectal Cancer Who Harbors a Germline Codon-Stop Mutation in.

Untitled by Martin Blank

Direct-to-Consumer Testing 2

Whole-Genome Sequencing in Healthy People

Gestational Trophoblastic Disease

Bronze Statues by Jane DeDecker

Volume 152, Issue 6, Pages (May 2017)

Sister Mary Joseph’s Nodule

Management of Patients With Aortic Valve Stenosis

Topical Analgesics in the Management of Acute and Chronic Pain

Comparative Effectiveness and Cost Effectiveness of a Multitarget Stool DNA Test to Screen for Colorectal Neoplasia Uri Ladabaum, Ajitha Mannalithara

Recommended Intervals Between Screening and Surveillance Colonoscopies

Acupuncture Mayo Clinic Proceedings

Madonna della Pietá by Michelangelo

Applique Quilt Prince's Feather Pattern – Circa 1845

Metastatic Breast Cancer

Pancreatic Ductal Adenocarcinoma

Barbara P. Yawn, MD, MSc, MSPH, MeiLan K. Han, MD, MS

Patient-Initiated Second Opinions: Systematic Review of Characteristics and Impact on Diagnosis, Treatment, and Satisfaction Velma L. Payne, PhD, Hardeep.

Capacity Coaching: A New Strategy for Coaching Patients Living With Multimorbidity and Organizing Their Care Kasey R. Boehmer, PhD, MPH, Nicole M. Guerton,

Refurbishing Mayo Clinic Proceedings:

Pharmacogenomics: Precision Medicine and Drug Response

Best Practices for Patients With Chronic Migraine

Classic Hodgkin Lymphoma

Pleomorphic Adenoma in the Parotid Gland

Evaluation and Management of Penicillin Allergy

Jöns Jacob Berzelius – A Father of Chemistry

IGS V, Series #4 by Marvin B. Lipofsky

Kenneth N. Huynh, BS, Ba D. Nguyen, MD Mayo Clinic Proceedings

Institutional Review Boards: What Clinician Researchers Need to Know

Diabetic Mastopathy Mayo Clinic Proceedings

Simon M. Glynn, MD, Sean J. Pittock, MD, Steven A. Vernino, MD, PhD

Leadership Models in Health Care—A Case for Servant Leadership

Lila J. Finney Rutten, PhD, MPH, Robert M. Jacobson, MD, Patrick M

Hepatocellular Carcinoma

David P. Steensma, MD, Robert A. Kyle, MD Mayo Clinic Proceedings

Methylphenidate: Its Pharmacology and Uses

Down River by Charles Munch

Pancreatic Tumor in a Patient With Parathyroid and Pituitary Disease

Celebrating the Sesquicentennial of Mayo Clinic: 150 Years of Advances in Medical Practice, Education, Research, and Professionalism William L. Lanier,

Lowering the High Cost of Cancer Drugs—IV

Serum Alkalinization and Hydrogen-Rich Water in Healthy Men

Mantle Cell Involvement of the Spleen

Squamous Cell Carcinoma of the Tongue

Trends in Prevalence of Functional Disability in Rheumatoid Arthritis Compared With the General Population Elena Myasoedova, MD, PhD, John M. Davis,

Preoperative Smoking Cessation: The Role of the Primary Care Provider

Pink Manta by Joseph Pagano

Minnesota Birds and Flora by Emily Wilson

Diagnosis and Management of Headache in Older Adults

Mayo Clinic Proceedings 2012: “A New Era in Journal Stewardship”

Presentation transcript:

Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People Diana G. Redwood, PhD, Elvin D. Asay, MS, Ian D. Blake, MS, Pamela E. Sacco, RN, Claudia M. Christensen, ANP, Frank D. Sacco, MD, James J. Tiesinga, MD, Mary E. Devens, BA, Steven R. Alberts, MD, Douglas W. Mahoney, MS, Tracy C. Yab, BS, Patrick H. Foote, MD, Thomas C. Smyrk, MD, Ellen M. Provost, DO, David A. Ahlquist, MD Mayo Clinic Proceedings Volume 91, Issue 1, Pages 61-70 (January 2016) DOI: 10.1016/j.mayocp.2015.10.008 Copyright © 2016 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Study enrollment flow diagram. FIT = fecal immunochemical test; GI = gastrointestinal; IBD = inflammatory bowel disease; MT-sDNA = multitarget stool DNA test; SRN = screening-relevant colorectal neoplasia. Mayo Clinic Proceedings 2016 91, 61-70DOI: (10.1016/j.mayocp.2015.10.008) Copyright © 2016 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Effects of polyp size and patient age on test performances. A, Comparative detection rates of all advanced adenomas based on polyp size cutoff. Advanced adenomas included both adenomatous and sessile serrated adenoma/polyp types. B, Comparative detection rates of the sessile serrated adenoma/polyp subset based on size cutoff. C, Comparative false-positive rates by patient age. FIT = fecal immunochemical test; MT-sDNA = multitarget stool DNA test. Mayo Clinic Proceedings 2016 91, 61-70DOI: (10.1016/j.mayocp.2015.10.008) Copyright © 2016 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 3 Test comparisons for number of patients who needed to be screened to detect one screening-relevant neoplasm (SRN), advanced adenoma, or colorectal cancer (CRC). FIT = fecal immunochemical test; MT-sDNA = multitarget stool DNA test. Mayo Clinic Proceedings 2016 91, 61-70DOI: (10.1016/j.mayocp.2015.10.008) Copyright © 2016 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 4 Comparison of colorectal neoplasm detection rates by MT-sDNA in Alaska Native people (present study) vs general US population.25 Mayo Clinic Proceedings 2016 91, 61-70DOI: (10.1016/j.mayocp.2015.10.008) Copyright © 2016 Mayo Foundation for Medical Education and Research Terms and Conditions