PowerLecture: Chapter 12 Chromosomes and Human Inheritance

Philadelphia Chromosome _______________________________________________

Sex Chromosomes __________________________ __________________ ___________________________________________

Karyotype Preparation Fig. 12-3a-e, p.189

Karyotype Diagram Fig. 12-3f, p.189

Autosomal Dominant Inheritance _______________________________________ Fig. 12-10a, p. 190

Autosomal Dominant Inheritance example… __________________ Fig. 12-5, p.190

Achondroplasia _______________________________

Huntington Disorder ________________________________ ________________________________________________

Autosomal Recessive Inheritance Patterns ______________________________________________________________________ Fig. 12-10b, p. 191

Galactosemia _______________________________ _______________________________________ lactose galactose enzyme 1 + glucose galactose-1- phosphate enzyme 2 galactose-1- phosphate enzyme 3 intermediate in glycolysis

Hutchinson-Gilford Progeria __________________________________

The Y Chromosome ________________________________ __________________________________________________________________________

The X Chromosome ___________________________ _____________________________________________________________

Thomas Morgan ______________________ ________________________________________________________ _________ __________________________________

Examples of X-Linked Traits _________________________

Duplication ______________________________________________

Duplication normal chromosome one segment repeated three repeats

Deletion _________________________________

Inversion __________________ In-text figure Page 196 segments G, H, I become inverted In-text figure Page 196

Translocation ____________________________________________________________________ _____________________

Translocation one chromosome In-text figure Page 206 a nonhomologous nonreciprocal translocation In-text figure Page 196

Duplications & Translocations ____________________________________________________________________ Fig. 12-14, p.197

Chromosome Structure ______________________________________________ ____________________________________________________________________ ______________________

Chromosome Structure _______________ __________________________________ ____________________________________________________________________

Chromosome Structure human chimpanzee gorilla orangutan Fig. 12-15, p.197

Aneuploidy ___________________________________________ ______________

Polyploidy ________________________________________________________________ ______________________

Nondisjunction n + 1 n + 1 n - 1 n - 1 chromosome alignments at metaphase I NONDISJUNCTION AT ANAPHASE I alignments at metaphase II anaphase II CHROMOSOME NUMBER IN GAMETES Fig. 12-16b, p.198

Nondisjunction ___________________________

Down Syndrome Fig. 12-17, p.199

Nondisjunction _________________________________ _____________

Fig. 12-19b,p.200

Phenotypic Treatments ___________________________________________________________ ______________ ____________________________________ ______________________

Genetic Screening ______________________________________________ _________________________________________________

Preimplantation Diagnosis ____________________ ____________________________________________________ __________________________________________