Antibiotics: A New Hope

Slides:

Advertisements

Similar presentations

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.

Advertisements

Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics Weng Ruh Wong, Allen G. Oliver,

The Biosynthesis of Teicoplanin-Type Glycopeptide Antibiotics: Assignment of P450 Mono-Oxygenases to Side Chain Cyclizations of Glycopeptide A47934 Bianka.

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &

Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages (April 2010) DOI: /j.tics

In Vivo Photoswitchable Flow Cytometry for Direct Tracking of Single Circulating Tumor Cells Dmitry A. Nedosekin, Vladislav V. Verkhusha, Alexander V.

A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi.

Biocompatible Quantum Dots for Biological Applications Sandra J. Rosenthal, Jerry C. Chang, Oleg Kovtun, James R. McBride, Ian D. Tomlinson Chemistry &

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates Bradley Croy Doak, Bj ӧ rn Over, Fabrizio Giordanetto, Jan Kihlberg.

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Yves Pommier, Elisabetta Leo, HongLiang Zhang, Christophe Marchand Chemistry.

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria Alban Pereira, Zhengyu Cao, Thomas.

Context-Specific Target Definition in Influenza A Virus Hemagglutinin-Glycan Receptor Interactions Zachary Shriver, Rahul Raman, Karthik Viswanathan, Ram.

Staphylococcus aureus and Bacillus subtilis W23 Make Polyribitol Wall Teichoic Acids Using Different Enzymatic Pathways Stephanie Brown, Timothy Meredith,

The Efficacy of siRNAs against Hepatitis C Virus Is Strongly Influenced by Structure and Target Site Accessibility Selena M. Sagan, Neda Nasheri, Christian.

Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage John Tam, Greg L. Beilhartz, Anick Auger, Pulkit Gupta, Alex G. Therien,

Cationic Fullerenes Are Effective and Selective Antimicrobial Photosensitizers George P. Tegos, Tatiana N. Demidova, Dennisse Arcila-Lopez, Haeryeon Lee,

Glycosidase Inhibition by Macrolide Antibiotics Elucidated by STD-NMR Spectroscopy Ali Sadeghi-Khomami, Michael D. Lumsden, David L. Jakeman Chemistry.

Functional Studies of Plasmodium falciparum Dipeptidyl Aminopeptidase I Using Small Molecule Inhibitors and Active Site Probes Edgar Deu, Melissa J. Leyva,

Dizziness in older adults

Nucleosomes and Cisplatin

Volume 22, Issue 5, Pages v-vi (May 2015)

Now Playing: Farnesol in the Biofilm

Enzyme Annotation with Chemical Tools

New Light on Methylthiolation Reactions

Tailor-Made Peptide Synthetases

Nucleosomes and Cisplatin

On-Bead Library Screening Made Easier

Foundations for Directed Alkaloid Biosynthesis

Nature’s Strategy for Catalyzing Diels-Alder Reaction

Scratch n’ Screen for Inhibitors of Cell Migration

Chemical Proteomics of Host-Pathogen Interaction

Matthieu Desroses, Mikael Altun Cell Chemical Biology

In Search of the Missing Ligands for TetR Family Regulators

Adding Specificity to Artificial Transcription Activators

Finding the Missing Code of RNA Recognition by PUF Proteins

Redefining Clinical Trials: The Age of Personalized Medicine

News in Ubiquinone Biosynthesis

Tandem Modifications of an Epoxyquinone C7N Pharmacophore

JAK3 Specific Kinase Inhibitors: When Specificity Is Not Enough

Activity-Based Profiling of 2-Oxoglutarate Oxygenases

Targeting the Undruggable Proteome: The Small Molecules of My Dreams

Detection of Activated, TIMP-free MMPs

A Noncanonical Path to Mechanism of Action

Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone

No Need To Be Pure: Mix the Cultures!

Resolving Resolvins Chemistry & Biology

Activity-Based Profiling for Drug Discovery

Now Playing: Farnesol in the Biofilm

HAT Trick: p300, Small Molecule, Inhibitor

Resisting resistance: new chemical strategies for battling superbugs

BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons

Making a New Turn In Matrix Metalloprotease Inhibition

Volume 21, Issue 9, Pages (September 2014)

Volume 21, Issue 8, Pages v-vi (August 2014)

Foundations for Directed Alkaloid Biosynthesis

Discrimination between Two Endocannabinoids

Redesigning the Architecture of the Base Pair: Toward Biochemical and Biological Function of New Genetic Sets Andrew T. Krueger, Eric T. Kool Chemistry.

Luca Sartori, Saverio Minucci Chemistry & Biology

Nature’s Strategy for Catalyzing Diels-Alder Reaction

L-DOPA Ropes in tRNAPhe

Volume 7, Issue 6, Pages R147-R151 (June 2000)

Volume 21, Issue 9, Pages (September 2014)

Urea Transporter Inhibitors: En Route to New Diuretics

Self-Assembling, Dynamic αPNAs

Tools to Tackle Protein Acetylation

Tariq A. Mukhtar, Kalinka P. Koteva, Gerard D. Wright

Volume 21, Issue 9, Pages (September 2014)

Volume 18, Issue 5, Pages R198-R202 (March 2008)

Volume 22, Issue 4, Pages vii-viii (April 2015)

Presentation transcript:

Antibiotics: A New Hope Gerard D. Wright Chemistry & Biology Volume 19, Issue 1, Pages 3-10 (January 2012) DOI: 10.1016/j.chembiol.2011.10.019 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 New Antibiotics Approved for Human Use over the Past Decade These represent new scaffolds for medical application. Chemistry & Biology 2012 19, 3-10DOI: (10.1016/j.chembiol.2011.10.019) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 2 Antibiotics in Development Representative new agents in phase 2- and phase 3-stage clinical trials. NXL-104 is not an antibiotic per se but an inhibitor of β-lactmases. Chemistry & Biology 2012 19, 3-10DOI: (10.1016/j.chembiol.2011.10.019) Copyright © 2012 Elsevier Ltd Terms and Conditions